MS049 oxalate salt

Name: MS049 oxalate salt
Brand: Tocris Bioscience
SKU: 5685

Cat. No. 5685 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5685 has been discontinued.

View all Protein Arginine Methyltransferases products.

说明： Potent and selective PRMT4 and PRMT6 inhibitor

化学名： N-Methyl-4-(phenylmethoxy)-1-piperidineethanamine oxalate salt

纯度： ≥98% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for MS049 oxalate salt

Potent and selective PRMT4 and PRMT6 inhibitor (IC₅₀ values are 44 and 63 nM, respectively). Reduces Med12me2a and H3R2me2a levels in HEK293 cells in vitro.

To request the negative control for MS049, please fill out the MS049N request form on the SGC website.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MS049 probe summary on the SGC website.

技术数据 for MS049 oxalate salt

分子量	338.4
公式	C₁₅H₂₄N₂O.C₂H₂O₄
储存	Desiccate at RT
纯度	≥98% (HPLC)
PubChem ID	121513883
InChI Key	RWKUVRQLFRJTTR-UHFFFAOYSA-N
Smiles	CNCCN(CC2)CCC2OCC1=CC=CC=C1.OC(C(O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for MS049 oxalate salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for MS049 oxalate salt

参考文献是支持产品生物活性的出版物。

Shen et al (2016) Discovery of a potent, selective, and cell-active dual inhibitor of protein arginine methyltransferase 4 and protein arginine methyltransferase 6. J.Med.Chem. 59 9124 PMID: 27584694

Scheer et al (2019) A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat.Commun. 10 19 PMID: 30604761

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关键词: MS049 oxalate salt, MS049 oxalate salt supplier, PRMT4, PRMT6, protein, arginine, methyltransferases, inhibits, inhibitors, 1502816-23-0, Protein, Arginine, Methyltransferases, 5685, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.