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MSA 2

Cat. No. 7353 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Non-nucleotide STING agonist; orally bioavailable
化学名： 4-(5,6-Dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MSA 2

MSA 2 is a non-nucleotide STING agonist (EC50 values are 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively). Exhibits antitumor activity and stimulates interferon-β secretion in tumors. Induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models. Orally bioavailable.

化合物库 for MSA 2

MSA 2 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for MSA 2

分子量 294.32
公式 C14H14O5S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 129425-81-6
PubChem ID 23035251
InChI Key APCLRHPWFCQIMG-UHFFFAOYSA-N
Smiles COC1=CC2=C(C=C1OC)C=C(C(CCC(O)=O)=O)S2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MSA 2

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 29.43 100

制备储备液 for MSA 2

以下数据基于产品分子量 294.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.4 mL 16.99 mL 33.98 mL
5 mM 0.68 mL 3.4 mL 6.8 mL
10 mM 0.34 mL 1.7 mL 3.4 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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参考文献 for MSA 2

参考文献是支持产品生物活性的出版物。

Pan et al (2020) An orally available non-nucleotide STING agonist with antitumor activity. Science 369 eaba6098 PMID: 32820094

If you know of a relevant reference for MSA 2, please let us know.

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关键词: MSA 2, MSA 2 supplier, MSA2, STING, agonists, agonism, orally, bioavailable, STING-Dependent, Signaling, 7353, Tocris Bioscience

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