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说明： Potent and selective monocarboxylate transporter 4 (MCT4) inhibitor
化学名： 5-[2-[5-Chloro-2-[[(5-ethoxy-8-quinolinyl)sulfonyl]amino]phenyl]ethynyl]-4-methoxy-2-pyridinecarboxylic acid
纯度： ≥98% (HPLC)
生物活性 for MSC 4381
MSC 4381 is a potent and selective monocarboxylate transporter 4 (MCT4) inhibitor (IC50 = 77 nM; Ki = 11 nM). Inhibits lactate efflux in MDA-MB-231 cells (IC50 = 1 nM) and reduces viability of cells expressing high levels of MCT4.
许可信息
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MSC 4381 probe summary on the SGC website.
技术数据 for MSC 4381
| 分子量 | 537.97 |
| 公式 | C26H20ClN3O6S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2445185-57-7 |
| PubChem ID | 150189198 |
| InChI Key | FNBUZGRPJLEIMO-UHFFFAOYSA-N |
| Smiles | O=C(C1=NC=C(C(OC)=C1)C#CC2=CC(Cl)=CC=C2NS(=O)(C3=CC=C(C4=CC=CN=C43)OCC)=O)O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for MSC 4381
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 26.9 | 50 |
制备储备液 for MSC 4381
以下数据基于产品分子量 537.97。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.72 mL | 18.59 mL | 37.18 mL |
| 2.5 mM | 0.74 mL | 3.72 mL | 7.44 mL |
| 5 mM | 0.37 mL | 1.86 mL | 3.72 mL |
| 25 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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产品说明书 for MSC 4381
参考文献 for MSC 4381
参考文献是支持产品生物活性的出版物。
Heinrich et al (2021) Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic acid, a highly selective in vivo eseable chemical probe to dissect MCT4 biology. J.Med.Chem. 64 11904 PMID: 34382802
If you know of a relevant reference for MSC 4381, please let us know.
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关键词: MSC 4381, MSC 4381 supplier, MSC4381, MCT4, monocarboxylate, transporter, 4, inhibitor, inhibitors, inhibits, lactate, efflux, cell, viability, Monocarboxylate, Transporters, 8008, Tocris Bioscience
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