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Submit ReviewMSG 606
说明： Potent human MC1 receptor antagonist; also MC3 and MC5 partial agonist
纯度： ≥95% (HPLC)
生物活性 for MSG 606
MSG 606 is a potent human MC1 receptor antagonist (IC50 = 17 nM). Also partial agonist at human MC3 and MC5 receptors (EC50 values are 59 and 1300 nM, respectively). Exhibits binding affinity for A375 melanoma cells in vitro. Reverses morphine-induced hyperalgesia in female mice, with no effect in male mice. γMSH analog.
技术数据 for MSG 606
| 分子量 | 1347.51 |
| 公式 | C62H82N20O13S |
| 序列 |
XGHFRWCDRFG (Modifications: X = Butanoic acid, Phe-4 = D-Phe, Trp-6 = D-Trp, Gly-11 = C-terminal amide, Carba sulfide bridge: X-1 - Cys-7) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 1416983-77-1 |
| PubChem ID | 122177131 |
| InChI Key | QJBNFEXQHBDMQM-VTWSTLNFSA-N |
| Smiles | NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CSCCCC(=O)NCC(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC2=CNC3=C2C=CC=C3)C(=O)N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MSG 606
参考文献 for MSG 606
参考文献是支持产品生物活性的出版物。
Cai et al (2013) An unusual conformation of γ-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells. Biochemistry 52 752 PMID: 23276279
Juni et al (2010) Sex-specific mediation of opioid-induced hyperalgesia by the melanocortin-1 receptor. Anesthesiology 112 181 PMID: 19996949
Arout et al (2015) Spinal and supraspinal N-methyl-D-aspartate and melanocortin-1 receptors contribute to a qualitative sex difference in morphine-induced hyperalgesia. Physiol.Behav. 147 364 PMID: 25982086
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关键词: MSG 606, MSG 606 supplier, MSG606, potent, MC1, receptors, melanocortin, antagonists, partial, agonists, MC3, MC5, hyperalgesia, Melanocortin, Receptors, 5954, Tocris Bioscience
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