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Mycophenolate mofetil

Cat. No. 4102 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inosine monophosphate dehydrogenase (IMPDH) inhibitor
化学名： 6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid 2-(4-morpholinyl)ethyl ester
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Mycophenolate mofetil

Mycophenolate mofetil is an immunosuppressant prodrug of mycophenolic acid (MPA) (Cat. No. 1505). Hydrolyzed by esterases to release MPA, a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). Used to prevent organ rejection after transplantation. Displays inhibitory activity of lymphocyte functions. Inhibits type 1 collagen expression, enhances MMP-1 expression, and reduces α-smooth muscle actin gene expression.

化合物库 for Mycophenolate mofetil

Mycophenolate mofetil is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Mycophenolate mofetil

分子量 433.49
公式 C23H31NO7
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 128794-94-5
PubChem ID 5281078
InChI Key RTGDFNSFWBGLEC-SYZQJQIISA-N
Smiles O=C(OC2)C1=C2C(C)=C(OC)C(C/C=C(C)/CCC(OCCN3CCOCC3)=O)=C1O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Mycophenolate mofetil

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 43.35 100
ethanol 4.33 10

制备储备液 for Mycophenolate mofetil

以下数据基于产品分子量 433.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.53 mL 23.07 mL
5 mM 0.46 mL 2.31 mL 4.61 mL
10 mM 0.23 mL 1.15 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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产品说明书 for Mycophenolate mofetil

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Mycophenolate mofetil

参考文献是支持产品生物活性的出版物。

Allison and Eugui (1996) Purine metabolism and immunosuppressive effects of mycophen. mofetil (MMF). Clin.Transplant. 10 77 PMID: 8680053

Roos et al (2007) In vitro evidence for a direct antifibrotic role of the immunosuppressive drug mycophen. mofetil. J.Pharm.Exp.Ther. 321 583

If you know of a relevant reference for Mycophenolate mofetil, please let us know.

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关键词: Mycophenolate mofetil, Mycophenolate mofetil supplier, immunosuppressant, pro-drug, MMF, inhibits, inosine, monophosphate, dehydrogenase, IMPDH, Other, Dehydrogenases, Immunosuppressants, 4102, Tocris Bioscience

1 篇 Mycophenolate mofetil 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Mycophenolate mofetil 的部分引用包括：

Fikri Y et al (2022) Modulation of immunosuppressant drug treatment to improve SARS-CoV-2 vaccine efficacy in mice. Vaccine 40 854-861 PMID: 34991929

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