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Mycophenolic acid

Cat. No. 1505 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inosine monophosphatase dehydrogenase (IMPDH) inhibitor
化学名： 6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Mycophenolic acid

Mycophenolic acid is an immunosuppressive agent with antiviral and antitumor effects in vitro and in vivo. Potently inhibits inosine monophosphate dehydrogenase (IMPDH), thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. Reversibly inhibits proliferation of T and B lymphocytes and antibody formation.

化合物库 for Mycophenolic acid

Mycophenolic acid is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Mycophenolic acid

分子量 320.34
公式 C17H20O6
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 24280-93-1
PubChem ID 446541
InChI Key HPNSFSBZBAHARI-RUDMXATFSA-N
Smiles COC1=C(C)C2=C(C(=O)OC2)C(O)=C1C\C=C(/C)CCC(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Mycophenolic acid

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.03 100

制备储备液 for Mycophenolic acid

以下数据基于产品分子量 320.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.12 mL 15.61 mL 31.22 mL
5 mM 0.62 mL 3.12 mL 6.24 mL
10 mM 0.31 mL 1.56 mL 3.12 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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产品说明书 for Mycophenolic acid

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Mycophenolic acid

参考文献是支持产品生物活性的出版物。

Allison et al (1993) Mechanisms of action of mycophenolic acid. Ann.N.Y.Acad.Sci. 696 63 PMID: 7906496

Chapman et al (1997) Distinct inhibitory effects of spinal endomorphin-1 and endomorphin-2 on evoked dorsal horn neuronal responses in the rat. Br.J.Pharmacol. 122 1537 PMID: 9422796

Eugui et al (1991) Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depeletion. Scand.J.Immunol. 33 161 PMID: 1826793

Goldberg et al (1998) Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J.Pharmacol.Exp.Ther. 286 1007 PMID: 9694962

Senda et al (1995) Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells. Transplantation 60 1143 PMID: 7482723

Zadina et al (1997) A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386 499 PMID: 9087409

If you know of a relevant reference for Mycophenolic acid, please let us know.

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关键词: Mycophenolic acid, Mycophenolic acid supplier, Inosine, monophosphatase, dehydrogenases, inhibitors, inhibits, immunosuppressant, IMPDH, Other, Dehydrogenases, Immunosuppressants, Non-selective, Antivirals, 1505, Tocris Bioscience

1 篇 Mycophenolic acid 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Mycophenolic acid 的部分引用包括：

Gomez et al (2015) Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate. PLoS One 10 e0133862 PMID: 26288179

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Mycophenolic acid 的评论

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Used as an IMPDH inhibitor.
By Timothy Ryan on 09/30/2024
分析类型： Ex Vivo
种属： Rat
细胞系/组织： Primary hippocampal neurons

The drug was incubated at 2 μM for 2 h to deplete intracellular GTP.

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