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MYX 1715

Cat. No. 8109 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： N-myristoyltransferase (NMT) inhibitor
化学名： 4-[2-[2-[3-(2-Aminoethyl)imidazo[1,2-a]pyridin-6-yl]-5-chlorophenoxy]ethyl]-N,N,1,5-tetramethyl-1H-pyrazole-3-carboxamide dihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MYX 1715

MYX 1715 is a N-myristoyltransferase inhibitor (NMT). MYX 1715 selectively kills senescent cancer cells in mouse models of paediatric pituitary tumors and liver cancer, and prevents tumor growth in mouse xenografts. In mouse models of idiopathic pulmonary fibrosis (IPF) and NASH, MYX 1715 reduces both lung and liver fibrosis, and decreases inflammation and steatosis.

技术数据 for MYX 1715

分子量 553.91
公式 C25H29ClN6O2.2HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
InChI Key IPOQBMAKZNXYNK-UHFFFAOYSA-N
Smiles O=C(N(C)C)C1=NN(C)C(C)=C1CCOC2=C(C3=CN4C(CCN)=CN=C4C=C3)C=CC(Cl)=C2.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MYX 1715

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 55.39 100
water 55.39 100

制备储备液 for MYX 1715

以下数据基于产品分子量 553.91。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.81 mL 9.03 mL 18.05 mL
5 mM 0.36 mL 1.81 mL 3.61 mL
10 mM 0.18 mL 0.9 mL 1.81 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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参考文献 for MYX 1715

参考文献是支持产品生物活性的出版物。

McHugh et al (2023) COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells. Nat.Cell Biol. 25 1804 PMID: 38012402

If you know of a relevant reference for MYX 1715, please let us know.

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关键词: MYX 1715, MYX 1715 supplier, MYX1715, senescent, cancer, cells, tumor, steatosis, xenograft, non-alcoholic, steatohepatitis, idiopathic, pulmonary, fibrosis, in, vivo, IMP1320, Other, Transferases, 8109, Tocris Bioscience

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