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N-Acetylpuromycin

Cat. No. 5679 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Downregulates SnoN and Ski protein expression; promotes TGF-β signaling
化学名： 3'-[[(2S)-2-(Acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (3)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for N-Acetylpuromycin

N-Acetylpuromycin downregulates SnoN and Ski protein expression; promotes TGF-β signaling, independently of MAPK activation. Does not bind ribosomes or block protein synthesis.

技术数据 for N-Acetylpuromycin

分子量 513.55
公式 C24H31N7O6
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 22852-13-7
PubChem ID 46173769
InChI Key LADKVYSQIGJMFP-IYRMOJGWSA-N
Smiles O[C@@H]1[C@H](NC([C@@H](NC(C)=O)CC4=CC=C(OC)C=C4)=O)[C@@H](CO)O[C@H]1N3C2=NC=NC(N(C)C)=C2N=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for N-Acetylpuromycin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 51.35 100
1eq. HCl 51.35 100

制备储备液 for N-Acetylpuromycin

以下数据基于产品分子量 513.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.74 mL 19.47 mL
5 mM 0.39 mL 1.95 mL 3.89 mL
10 mM 0.19 mL 0.97 mL 1.95 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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产品说明书 for N-Acetylpuromycin

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for N-Acetylpuromycin

参考文献是支持产品生物活性的出版物。

Hernández-Damián et al (2013) Downregulation of SnoN oncoprotein induced by antibiotics anisomycin and puromycin positively regulates transforming growth factor-β signals. Biochim.Biophys.Acta. 1830 5049 PMID: 23872350

If you know of a relevant reference for N-Acetylpuromycin, please let us know.

按标靶查看相关产品

关键词: N-Acetylpuromycin, N-Acetylpuromycin supplier, SnoN, SKI, proteins, downregulates, downregulation, transforming, growth, factor, beta, TGF-beta, TGF-B, TGF-β, signaling, ribosomes, Receptors, 5679, Tocris Bioscience

2 篇 N-Acetylpuromycin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 N-Acetylpuromycin 的部分引用包括：

Alun R et al (2020) A Semiautomated, Phenotypic, In Vitro Scratch Assay for Assessing Retinal Pigment Epithelial Cell Wound Healing. J Ocul Pharmacol Ther 36 257-266 PMID: 32027217

Hossein et al (2020) Directed differentiation of regulatory T cells from naive T cells and prevention of their inflammation-mediated instability using small molecules. Clin Exp Immunol 201 205-221 PMID: 32403163

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Stem Cell Research Product Guide

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

  • Self-renewal and Maintenance
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  • Organoid Generation
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Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Stem Cells Poster

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

Pathways for N-Acetylpuromycin

TGF-β Signaling Pathway

TGF-β Signaling Pathway

The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.