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N-Arachidonylglycine

Cat. No. 1445 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： GPR18 agonist; endocannabinoid
别名： NAGly
化学名： N-(1-oxo-5Z,8Z,11Z,14Z-eicosatetraenyl)glycine
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for N-Arachidonylglycine

N-Arachidonylglycine is a GPR18 agonist (EC50 = 44.5 nM). Endogenous anandamide-like compound. Lacks affinity for CB1 receptors (Ki > 10 μM), VR1 receptors (EC50 > 10 μM) and anandamide transporters (IC50 > 50 μM) but causes hot-plate analgesia in mice when given orally, and suppresses tonic inflammatory pain. Also endogenous GlyT2 inhibitor.

技术数据 for N-Arachidonylglycine

分子量 361.52
公式 C22H35NO3
储存 Desiccate at -20°C
纯度 ≥98% (HPLC)
CAS Number 179113-91-8
PubChem ID 5283389
InChI Key YLEARPUNMCCKMP-DOFZRALJSA-N
Smiles O=C(NCC(O)=O)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for N-Arachidonylglycine

分析证书/产品说明书
化学品安全技术说明书

参考文献 for N-Arachidonylglycine

参考文献是支持产品生物活性的出版物。

Burnstein et al (2000) Oxidative metabolism of anandamide. Prostaglandins Other Lipid Mediat. 61 29 PMID: 10785540

Edington et al (2009) Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport. J.Biol.Chem. 284 36424 PMID: 19875446

Huang et al (2001) Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. J.Biol.Chem. 276 42639 PMID: 11518719

Sheskin et al (1997) Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor. J.Med.Chem. 40 659 PMID: 9057852

Kohno et al (2006) Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18. Biochem Biophys Res Commun. 347 827 PMID: 16844083

McHugh et al (2012) Δ9-Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells Br.J.Pharmacol. 2414 165 PMID: 21595653

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关键词: N-Arachidonylglycine, N-Arachidonylglycine supplier, endocannabinoids, Suppresses, pain, vivo, Receptors, NAGly, Other, Cannabinoids, Glycine, Transporters, 1445, Tocris Bioscience

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