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Submit ReviewN-Desmethylclozapine
说明： 5-HT2C antagonist
别名： Normethylclozapine,Norclozapine
化学名： 8-Chloro-11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
纯度： ≥99% (HPLC)
生物活性 for N-Desmethylclozapine
N-Desmethylclozapine is an a major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist.
技术数据 for N-Desmethylclozapine
| 分子量 | 312.8 |
| 公式 | C17H17ClN4 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 6104-71-8 |
| PubChem ID | 210172 |
| InChI Key | NIBOMXUDFLRHRV-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C2NC3=C(C=CC=C3)C(=NC2=C1)N1CCNCC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for N-Desmethylclozapine
参考文献 for N-Desmethylclozapine
参考文献是支持产品生物活性的出版物。
Fox and Brotchie (1996) Normethylclozapine potentiates the action of quinpirole in the 6-hydroxyDA lesioned rat. Eur.J.Pharmacol. 301 27 PMID: 8773443
Kuoppamäki et al (1993) Clozapine and methylclozapine are potent 5-HT1C receptor antagonists. Eur.J.Pharmacol. 245 179 PMID: 8387927
Wong et al (1996) Effects of cloz. metabolites and chronic cloz. treatment on rat brain GABAA receptors. Eur.J.Pharmacol. 314 319 PMID: 8957253
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关键词: N-Desmethylclozapine, N-Desmethylclozapine supplier, 5-HT2C, antagonists, Serotonin, Receptors, Norclozapine, Normethylclozapine, 1007, Tocris Bioscience
3 篇 N-Desmethylclozapine 的引用文献
引用文献是使用了 Tocris 产品的出版物。 N-Desmethylclozapine 的部分引用包括：
Gregory et al (2010) Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias. J Biol Chem 285 7459 PMID: 20051519
Magliaro and Saldanha (2009) Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation. Brain Res 1283 14 PMID: 19501068
Sur et al (2003) N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-MthD.-aspartate receptor activity. Proc Natl Acad Sci U S A 100 13674 PMID: 14595031
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.