N-Formyl-Met-Leu-Phe

Pricing Availability   Qty
说明: Endogenous FPR1 agonist
别名: fMLP
纯度: ≥95% (HPLC)
说明书
引用文献 (2)
评论

生物活性 for N-Formyl-Met-Leu-Phe

N-Formyl-Met-Leu-Phe is an endogenous chemotactic peptide and agonist for the formyl peptide receptor 1 (FPR1) (Ki = 38 nM). Stimulates aggregation of leukocytes.

技术数据 for N-Formyl-Met-Leu-Phe

分子量 437.55
公式 C21H31N3O5S
序列 MLF

(Modifications: Met-1 = N-formyl-Met)

储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 59880-97-6
PubChem ID 443295
InChI Key PRQROPMIIGLWRP-BZSNNMDCSA-N
Smiles CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for N-Formyl-Met-Leu-Phe

溶解性 Soluble to 4 mg/ml in DMSO

产品说明书 for N-Formyl-Met-Leu-Phe

分析证书/产品说明书
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参考文献 for N-Formyl-Met-Leu-Phe

参考文献是支持产品生物活性的出版物。

Kreutzer et al (1978) Quantitative comparisons of various biological responses of neutrophils to different active and inactive chemotactic factors. Immunopharmacology 1 39 PMID: 45788

Mills et al (2000) Characterization of the binding site on the formyl peptide receptor using three receptor mutants and analogs of Met-Leu-Phe and Met-Met-Trp-Leu-Leu. J.Biol.Chem. 275 39012 PMID: 10960471

Spilberg et al (1984) Receptor blockade as a mechanism of deactivation of human neutrophils by pepstatin and formyl-Met-Leu-Phe. Inflammation 8 73 PMID: 6325345


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关键词: N-Formyl-Met-Leu-Phe, N-Formyl-Met-Leu-Phe supplier, Endogenous, FPR1, agonists, FPRL, Formyl, Peptide, Receptors, fMLP, fMLF, 1921, Tocris Bioscience

2 篇 N-Formyl-Met-Leu-Phe 的引用文献

引用文献是使用了 Tocris 产品的出版物。 N-Formyl-Met-Leu-Phe 的部分引用包括:

Tomilov et al (2010) Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice. J Biol Chem 285 1153 PMID: 19892704

Ding et al (2017) DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone. Mediators Inflamm 2017 2642549 PMID: 28804219


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