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Submit ReviewN-Formyl-Met-Leu-Phe is an endogenous chemotactic peptide and agonist for the formyl peptide receptor 1 (FPR1) (Ki = 38 nM). Stimulates aggregation of leukocytes.
分子量 | 437.55 |
公式 | C21H31N3O5S |
序列 |
MLF (Modifications: Met-1 = N-formyl-Met) |
储存 | Store at -20°C |
纯度 | ≥95% (HPLC) |
CAS Number | 59880-97-6 |
PubChem ID | 443295 |
InChI Key | PRQROPMIIGLWRP-BZSNNMDCSA-N |
Smiles | CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性 | Soluble to 4 mg/ml in DMSO |
参考文献是支持产品生物活性的出版物。
Kreutzer et al (1978) Quantitative comparisons of various biological responses of neutrophils to different active and inactive chemotactic factors. Immunopharmacology 1 39 PMID: 45788
Mills et al (2000) Characterization of the binding site on the formyl peptide receptor using three receptor mutants and analogs of Met-Leu-Phe and Met-Met-Trp-Leu-Leu. J.Biol.Chem. 275 39012 PMID: 10960471
Spilberg et al (1984) Receptor blockade as a mechanism of deactivation of human neutrophils by pepstatin and formyl-Met-Leu-Phe. Inflammation 8 73 PMID: 6325345
If you know of a relevant reference for N-Formyl-Met-Leu-Phe, please let us know.
关键词: N-Formyl-Met-Leu-Phe, N-Formyl-Met-Leu-Phe supplier, Endogenous, FPR1, agonists, FPRL, Formyl, Peptide, Receptors, fMLP, fMLF, 1921, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 N-Formyl-Met-Leu-Phe 的部分引用包括:
Tomilov et al (2010) Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice. J Biol Chem 285 1153 PMID: 19892704
Ding et al (2017) DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone. Mediators Inflamm 2017 2642549 PMID: 28804219
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