N-Formyl-Met-Leu-Phe

Cat. No. 1921 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Endogenous FPR1 agonist

别名： fMLP

纯度： ≥95% (HPLC)

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for N-Formyl-Met-Leu-Phe

N-Formyl-Met-Leu-Phe is an endogenous chemotactic peptide and agonist for the formyl peptide receptor 1 (FPR1) (K_i = 38 nM). Stimulates aggregation of leukocytes.

技术数据 for N-Formyl-Met-Leu-Phe

分子量	437.55
公式	C₂₁H₃₁N₃O₅S
序列	MLF (Modifications: Met-1 = N-formyl-Met)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	59880-97-6
PubChem ID	443295
InChI Key	PRQROPMIIGLWRP-BZSNNMDCSA-N
Smiles	CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for N-Formyl-Met-Leu-Phe

溶解性	Soluble to 4 mg/ml in DMSO

产品说明书 for N-Formyl-Met-Leu-Phe

分析证书/产品说明书

化学品安全技术说明书

参考文献 for N-Formyl-Met-Leu-Phe

参考文献是支持产品生物活性的出版物。

Kreutzer et al (1978) Quantitative comparisons of various biological responses of neutrophils to different active and inactive chemotactic factors. Immunopharmacology 1 39 PMID: 45788

Mills et al (2000) Characterization of the binding site on the formyl peptide receptor using three receptor mutants and analogs of Met-Leu-Phe and Met-Met-Trp-Leu-Leu. J.Biol.Chem. 275 39012 PMID: 10960471

Spilberg et al (1984) Receptor blockade as a mechanism of deactivation of human neutrophils by pepstatin and formyl-Met-Leu-Phe. Inflammation 8 73 PMID: 6325345

If you know of a relevant reference for N-Formyl-Met-Leu-Phe, please let us know.

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关键词: N-Formyl-Met-Leu-Phe, N-Formyl-Met-Leu-Phe supplier, Endogenous, FPR1, agonists, FPRL, Formyl, Peptide, Receptors, fMLP, fMLF, 1921, Tocris Bioscience

2 篇 N-Formyl-Met-Leu-Phe 的引用文献

引用文献是使用了 Tocris 产品的出版物。 N-Formyl-Met-Leu-Phe 的部分引用包括：

Ding et al (2017) DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone. Mediators Inflamm 2017 2642549 PMID: 28804219

Tomilov et al (2010) Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice. J Biol Chem 285 1153 PMID: 19892704

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