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Submit ReviewN-methylated pomalidomide
说明： Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control
化学名： 4-Amino-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
纯度： ≥95% (HPLC)
生物活性 for N-methylated pomalidomide
N-methylated pomalidomide is a functionalized cereblon ligand for PROTAC® research and development. Can be used to generate negative controls for Pomalidomide (Cat. No. 6302)-based Degraders. Does not bind to cereblon. Part of a range of functionalized tool molecules for PROTAC R&D. Can also be used as a Pomalidomide negative control.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
技术数据 for N-methylated pomalidomide
| 分子量 | 287.27 |
| 公式 | C14H13N3O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 1352827-50-9 |
| PubChem ID | 58572149 |
| InChI Key | YSWQOCGODHPKED-UHFFFAOYSA-N |
| Smiles | O=C1C=2C=CC=C(N)C2C(=O)N1C3C(=O)N(C(=O)CC3)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for N-methylated pomalidomide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 28.73 | 100 |
制备储备液 for N-methylated pomalidomide
以下数据基于产品分子量 287.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.48 mL | 17.41 mL | 34.81 mL |
| 5 mM | 0.7 mL | 3.48 mL | 6.96 mL |
| 10 mM | 0.35 mL | 1.74 mL | 3.48 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.7 mL |
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产品说明书 for N-methylated pomalidomide
参考文献 for N-methylated pomalidomide
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关键词: N-methylated pomalidomide, N-methylated pomalidomide supplier, protacs, negative, control, proteolysis, targeting, chimera, cereblon, E3, CRBN, 1352827-50-9, ubiquitin, ligase, Functionalized, Ligase, Ligands, Ubiquitin, Ligases, 7716, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia