N¹,N¹¹-Diethylnorspermine tetrahydrochloride

Cat. No. 0468 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Spermine and spermidine acetyltransferase potentiator

化学名： N,N'-bis[3-(Ethylamino)propyl]-1,3-propanediamine tetrahydrochloride

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性

N¹,N¹¹-Diethylnorspermine tetrahydrochloride is a highly potent inducer of spermidine/spermine N¹-acetyltransferase, able to increase enzyme activity 200-1000 fold.

技术数据

分子量	390.27
公式	C₁₃H₃₂N₄.4HCl
储存	Store at RT
CAS Number	156886-85-0
PubChem ID	11501988
InChI Key	LAWBSOKBIROCQP-UHFFFAOYSA-N
Smiles	CCNCCCNCCCNCCCNCC.Cl.Cl.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	39.03	100

制备储备液

以下数据基于产品分子量 390.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.56 mL	12.81 mL	25.62 mL
5 mM	0.51 mL	2.56 mL	5.12 mL
10 mM	0.26 mL	1.28 mL	2.56 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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产品说明书

分析证书/产品说明书

化学品安全技术说明书

参考文献

参考文献是支持产品生物活性的出版物。

Bernacki et al (1992) Antitumour activity of N¹,N¹²-bis(ethyl)spermine homologs against human MALME-3 melanoma xenografts. Cancer Res. 52 2424 PMID: 1568212

Fogel-Petrovic et al (1997) Structural basis for differential induction of spermidine/spermine N¹-acetyltransferase activity by novel spermine analogs. Mol.Pharmacol. 52 69 PMID: 9224814

Libby et al (1991) Characterization of human spermidine spermine N¹-acetyltransferase purified from cultured melanoma cells. Arch.Biochem.Biophys. 284 238 PMID: 1989509

Porter et al (1993) Antitumour activity of N¹,N¹²-bis(ethyl)-norspermine against human melanoma xenografts and possible biochemical correlates of drug action. Cancer Res. 53 581 PMID: 8425191

If you know of a relevant reference for N¹,N¹¹-Diethylnorspermine tetrahydrochloride, please let us know.

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关键词: N1,N11-Diethylnorspermine tetrahydrochloride, N1,N11-Diethylnorspermine tetrahydrochloride supplier, Spermine, spermidine, N1-acetyltransferase, potentiator, Acyltransferases, Transferases, Enzyme, Substrates, /, Activators, Other, 0468, Tocris Bioscience

1 篇 N¹,N¹¹-Diethylnorspermine tetrahydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 N¹,N¹¹-Diethylnorspermine tetrahydrochloride 的部分引用包括：

Sandusky-Beltran et al (2019) Spermidine/spermine-N1-acetyltransferase ablation impacts tauopathy-induced polyamine stress response. Alzheimers Res Ther 11 58 PMID: 31253191

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