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Submit ReviewNafadotride
说明： Highly potent, preferential D3 antagonist
化学名： N-[(1-Butyl-2-pyrrolidinyl)methyl]-4-cyano-1-methoxy-2-naphthalenecarboxamide
纯度： ≥98% (HPLC)
生物活性 for Nafadotride
Highly potent, competitive, preferential dopamine D3 receptor antagonist. Ki values are 0.52, 5, and 269 nM for human cloned D3, D2 and D4 receptors respectively. Centrally active upon systemic administration.
许可信息
Sold with the permission of INSERM and BIOPROJET
技术数据 for Nafadotride
| 分子量 | 365.47 |
| 公式 | C22H27N3O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 149649-22-9 |
| PubChem ID | 3408722 |
| InChI Key | IDZASIQMRGPBCQ-UHFFFAOYSA-N |
| Smiles | CCCCN1CCCC1CNC(=O)C1=C(OC)C2=CC=CC=C2C(=C1)C#N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Nafadotride
参考文献 for Nafadotride
参考文献是支持产品生物活性的出版物。
Audinot et al (1998) A comparative in vitro and in vivo pharmacological characterization of the novel DA D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J.Pharmacol.Exp.Ther. 287 187 PMID: 9765337
Richtand et al (2000) The DA D3 receptor antagonist nafadotride inhibits development of locomotor sensitization to amphetamine. Brain Res. 867 239 PMID: 10837819
Sautel et al (1995) Nafadotride, a potent preferential DA D3 receptor antagonist, activates locomotion in rodents. J.Pharmacol.Exp.Ther. 275 1239 PMID: 8531087
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关键词: Nafadotride, Nafadotride supplier, potent, preferential, D3, antagonists, Dopamine, Receptors, dopaminergic, 1347, Tocris Bioscience
2 篇 Nafadotride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Nafadotride 的部分引用包括：
Brewer et al (2014) DA D3 receptor dysfunction prevents anti-nociceptive effects of mor. in the spinal cord. Front Neural Circuits 8 62 PMID: 24966815
Clemens and Hochman (2004) Conversion of the modulatory actions of DA on spinal reflexes from depression to facilitation in D3 receptor knock-out mice. J Neurosci 24 11337 PMID: 15601940
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.