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Submit ReviewNaloxonazine dihydrochloride
Discontinued Product
0591 has been discontinued.
说明： Selective μ1 antagonist
化学名： Bis-[5-α-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)-morphinan-6-ylidene] hydrazine dihydrochloride
纯度： ≥98% (HPLC)
生物活性 for Naloxonazine dihydrochloride
Naloxonazine dihydrochloride is a potent opioid antagonist, selective for μ1 receptors.
技术数据 for Naloxonazine dihydrochloride
| 分子量 | 723.69 |
| 公式 | C38H42N4O6.2HCl |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 880759-65-9 |
| PubChem ID | 90479735 |
| InChI Key | VIAIHLLKDJKEKM-DCBBKWFGSA-N |
| Smiles | [H][C@@]12OC3=C(C=CC4=C3[C@@]15CCN([C@](C4)([C@@]5(CC/C2=N\N=C6CC[C@]7([C@]8(CC9=C%10C(O[C@@]/6([C@@]7%10CCN8CC=C)[H])=C(C=C9)O)[H])O)O)[H])CC=C)O.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Naloxonazine dihydrochloride
参考文献 for Naloxonazine dihydrochloride
参考文献是支持产品生物活性的出版物。
Paul et al (1988) Differential blockade by naloxonazine of two μ opiate actions: analgesic and inhibition of gastrointestinal transit. Eur.J.Pharmacol. 149 403 PMID: 2842168
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关键词: Naloxonazine dihydrochloride, Naloxonazine dihydrochloride supplier, Selective, antagonists, μ-opioid, mu-opioid, μ1-opioid, mu1-opioid, MOP, Receptors, OP3, Mu, Opioid, 0591, Tocris Bioscience
4 篇 Naloxonazine dihydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Naloxonazine dihydrochloride 的部分引用包括：
Yi et al (2015) Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions. BMC Cell Biol 22 49 PMID: 26150021
Smith et al (2016) Endogenous central amygdala mu-opioid receptor signaling promotes sodium appetite in mice. Proc Natl Acad Sci U S A 113 13893 PMID: 27849613
Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641
Lee et al (2012) Prostatic relaxation induced by loperamide is reduced in spontaneously hypertensive rats. J Biomed Sci 2012 941685 PMID: 22645476
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