NAV 2729

Cat. No. 5986 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective ARF6 inhibitor

化学名： 3-(4-Chlorophenyl)-5-(4-nitrophenyl)-2-(phenylmethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

纯度： ≥98% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for NAV 2729

NAV 2729 is a selective ARF6 inhibitor (IC₅₀ = 1.0 μM). Selective for ARF6 over other ARF family members and small GTPases. Inhibits ARF6 activation in uveal melanoma cells in vitro and blocks downstream signaling pathways of oncogenic GNAQ. Reduces tumorigenesis in mouse model of uveal melanoma.

化合物库 for NAV 2729

NAV 2729 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for NAV 2729

分子量	456.88
公式	C₂₅H₁₇ClN₄O₃
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	419547-11-8
PubChem ID	2257249
InChI Key	WHYGBVWGARJOCS-UHFFFAOYSA-N
Smiles	ClC1=CC=C(C2=C3NC(C4=CC=C([N+]([O-])=O)C=C4)=CC(N3N=C2CC5=CC=CC=C5)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NAV 2729

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	45.69	100

制备储备液 for NAV 2729

以下数据基于产品分子量 456.88。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.19 mL	10.94 mL	21.89 mL
5 mM	0.44 mL	2.19 mL	4.38 mL
10 mM	0.22 mL	1.09 mL	2.19 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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产品说明书 for NAV 2729

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NAV 2729

参考文献是支持产品生物活性的出版物。

Yoo et al (2016) ARF6 is an actionable node that orchestrates oncogenic GNAQ signaling in uveal melanoma. Cancer Cell. 29 889 PMID: 27265506

If you know of a relevant reference for NAV 2729, please let us know.

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关键词: NAV 2729, NAV 2729 supplier, NAV2729, small, G, proteins, Gαq, GTPases, inhibitors, inhibits, selective, ARF6, GNAQ, Arf, 5986, Tocris Bioscience