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NBC 19

Cat. No. 6722 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent NLRP3 inflammasome inhibitor
化学名： (T4)-[2-Acetyl-4,4,4-trichloro-N-cyclohexyl-3-(imino-κN)butanamidato-κO]diphenylboron
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NBC 19

NBC 19 is a potent NLRP3 inflammasome inhibitor (IC50 = 60-80 nM). Inhibits nigericin- and ATP-induced IL-1β release.

许可信息

Sold under license from the University of Manchester.

技术数据 for NBC 19

分子量 491.64
公式 C24H26BCl3N2O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2068818-75-5
InChI Key XLUPBOKHLVUFLX-UHFFFAOYSA-N
Smiles CC(C1=C(C(Cl)(Cl)Cl)N[B-](C2=CC=CC=C2)(C3=CC=CC=C3)[O+]=C1NC4CCCCC4)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NBC 19

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 49.16 100
ethanol 49.16 100

制备储备液 for NBC 19

以下数据基于产品分子量 491.64。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.17 mL 20.34 mL
5 mM 0.41 mL 2.03 mL 4.07 mL
10 mM 0.2 mL 1.02 mL 2.03 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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参考文献 for NBC 19

参考文献是支持产品生物活性的出版物。

Baldwin et al (2017) Boron-Based Inhibitors of the NLRP3 Inflammasome. Cell Chem.Biol. 24 1321 PMID: 28943355

Redondo-Castro et al (2018) Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses. Sci.Rep. 8 5667 PMID: 29618797

If you know of a relevant reference for NBC 19, please let us know.

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关键词: NBC 19, NBC 19 supplier, NBC19, Potent, NLRP3, inhibitors, inhibits, inflammasome, Inflammasomes, 6722, Tocris Bioscience

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