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NIBR LTSi

Cat. No. 8175 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective LATS inhibitor; activates YAP signaling
Chemical Name: N-[4-[(3R)-Piperidin-3-yl]oxyphenyl]-1H-pyrrolo[2,3-b]pyridin-4-amine
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for NIBR LTSi

NIBR-LTSi is a potent and selective large tumor suppressor kinase (LATS) inhibitor (IC50 = 1.4 nM). Also activates YAP signaling (EC50 = 1.0 - 2.7 μM). Promotes liver organoid formation (EC50 = 0.35 μM), hepatocyte proliferation, ISC expansion, and blocks differentiation. NIBR-LTSi is orally bioavailable and suitable for use in vivo and in vitro.

Technical Data for NIBR LTSi

M. Wt 308.39
Formula C18H20N4O
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 171115368
InChI Key IYFCFYWXRIVCTH-OAHLLOKOSA-N
Smiles C1(NC2=CC=C(O[C@H]3CNCCC3)C=C2)=CC=NC4=C1C=CN4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NIBR LTSi

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.84 100

Preparing Stock Solutions for NIBR LTSi

The following data is based on the product molecular weight 308.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.21 mL 32.43 mL
5 mM 0.65 mL 3.24 mL 6.49 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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References for NIBR LTSi

References are publications that support the biological activity of the product.

Namoto et al (2024) NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo. Cell Stem Cell 31 554 PMID: 38579685

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Citations for NIBR LTSi

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