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NBC 6

Cat. No. 6925 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： NLRP3 inflammasome inhibitor
化学名： (T4)-[2-Acetyl-4,4,4-trichloro-3-(imino-κN)butanamidito-κO]diphenylboron
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NBC 6

NBC 6 is a NLRP3 inflammasome inhibitor (IC50 = 574 nM). Inhibits nigericin-induced inflammasome activation in THP-1 cells and Imiquimod (Cat. No. 3700) induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs).

许可信息

Sold under license from the University of Manchester.

技术数据 for NBC 6

分子量 409.5
公式 C18H16BCl3N2O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2068818-02-8
PubChem ID 145237739
InChI Key VKECODDKRKQJNM-UHFFFAOYSA-N
Smiles CC(C1=C(C(Cl)(Cl)Cl)N[B-](C2=CC=CC=C2)(C3=CC=CC=C3)[O+]=C1N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NBC 6

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 40.95 100
ethanol 2.05 5

制备储备液 for NBC 6

以下数据基于产品分子量 409.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.21 mL 24.42 mL
5 mM 0.49 mL 2.44 mL 4.88 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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参考文献 for NBC 6

参考文献是支持产品生物活性的出版物。

Baldwin et al (2017) Boron-based inhibitors of the NLRP3 inflammasome. Cell Chem.Biol. 24 1321 PMID: 28943355

If you know of a relevant reference for NBC 6, please let us know.

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关键词: NBC 6, NBC 6 supplier, NBC6, inflammasome, inhibitors, inhibits, NLRP3, Inflammasomes, 6925, Tocris Bioscience

篇 NBC 6 的引用文献

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NBC 6 的评论

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NBC 6 can efficiently block pyroptosis induction.
By Xiaogang Wang on 06/12/2020
分析类型： In Vitro
种属： Human
细胞系/组织： THP-1 cells

We ordered this product, combining with another pyroptosis inhibitor NSA, to confirm the induction of pyroptosis by staphylococcal virulence factors. We have shown that NSA significantly inhibited the release of LDH by THP-1 cells treated with staphylococcal products. To confirm that tested staphylococcal product induces pyroptosis, we also used 20 uM NBC 6 to pretreat THP-1 cells before incubating with staphylococcal product. Similarly, treatment of THP-1 cells with NBC 6 also significantly decreased the release of LDH in THP-1 cells treated by staphylococcal product.

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