NBI 31772

Cat. No. 5192 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： High affinity insulin-like growth factor-I binding protein IGFBP inhibitor

化学名： 1-(3,4-Dihydroxybenzoyl)-6,7-dihydroxy-3-isoquinolinecarboxylic acid

纯度： ≥98% (HPLC)

引用文献 (2)

文献 (2)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for NBI 31772

NBI 31772 is a high affinity insulin-like growth factor-1 binding protein (IGFBP) inhibitor (K_i values are 1 - 24 nM for all six human subtypes). Displaces insulin-like growth factor-1 (IGF-1) from the IGF-1:IGFBP complex and suppresses IGF1-induced proliferation of 3T3 fibroblasts. Also increases cardiomyocyte proliferation in vivo.

技术数据 for NBI 31772

分子量	341.27
公式	C₁₇H₁₁NO₇
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	374620-70-9
PubChem ID	54684689
InChI Key	QUIWTBSOEFPLHE-FOCLMDBBSA-N
Smiles	O=C(C3=CC=C(O)C(O)=C3)C2=NC(C(O)=O)=CC1=CC(O)=C(O)C=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NBI 31772

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	34.13	100

制备储备液 for NBI 31772

以下数据基于产品分子量 341.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.93 mL	14.65 mL	29.3 mL
5 mM	0.59 mL	2.93 mL	5.86 mL
10 mM	0.29 mL	1.47 mL	2.93 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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产品说明书 for NBI 31772

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NBI 31772

参考文献是支持产品生物活性的出版物。

Chen et al (2001) Discovery of a series of nonpeptide small molecules that inhibit the binding of Ins-like growth factor (IGF) to IGF-binding proteins. J.Med.Chem. 44 4001 PMID: 11689087

Choi et al (2013) In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. Development. 140 660 PMID: 23293297

If you know of a relevant reference for NBI 31772, please let us know.

按标靶查看相关产品

关键词: NBI 31772, NBI 31772 supplier, NBI31772, High, affinity, insulin-like, growth, factor-1, binding, proteins, inhibitors, inhibits, IGFBP-3, IGF-1, cardiomyocytes, Insulin, and, Receptors, Insulin-like, 5192, Tocris Bioscience

2 篇 NBI 31772 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NBI 31772 的部分引用包括：

Ichijo et al (2017) Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration. Nat Commun 8 508 PMID: 28894084

Markus et al (2017) An O-Glycosylation of Fibronectin Mediates Hepatic Osteodystrophy Through α4β1 Integrin. J Bone Miner Res 32 70-81 PMID: 27427791

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Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.