NBMPR

Cat. No. 2924 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Equilibrative nucleoside transporter 1 (ENT1) inhibitor

化学名： 6-S-[(4-Nitrophenyl)methyl]-6-thioinosine

纯度： ≥99% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for NBMPR

NBMPR is an equilibrative nucleoside transporter 1 (ENT1) inhibitor (K_i values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).

化合物库 for NBMPR

NBMPR is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for NBMPR

分子量	419.41
公式	C₁₇H₁₇N₅O₆S
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	38048-32-7
PubChem ID	65407
InChI Key	DYCJFJRCWPVDHY-LSCFUAHRSA-N
Smiles	OC[C@H]1O[C@@H](N2C=NC3=C2N=CN=C3SCC4=CC=C([N+]([O-])=O)C=C4)[C@H](O)[C@@H]1O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NBMPR

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	41.94	100

制备储备液 for NBMPR

以下数据基于产品分子量 419.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.92 mL	23.84 mL
5 mM	0.48 mL	2.38 mL	4.77 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

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产品说明书 for NBMPR

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NBMPR

参考文献是支持产品生物活性的出版物。

Ward et al (2000) Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENT1 and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells. J.Biol.Chem. 275 8375 PMID: 10722669

Tsujie et al (2007) Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer. Anticancer Res. 27 2241 PMID: 17695509

Lin and Buolamwini (2007) Synthesis and flow cytometric evaluation, and identification of highly potent dipyrid. analogues as equilibrative nucleoside transporter 1 inhibitors. J.Med.Chem. 50 3906 PMID: 17636949

If you know of a relevant reference for NBMPR, please let us know.

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