NCT 501 hydrochloride

Cat. No. 5934 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective ALDH1A1 inhibitor

化学名： 8-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)-1H-purine-2,6-dione hydrochloride

纯度： ≥98% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for NCT 501 hydrochloride

NCT 501 hydrochloride is a potent and selective ALDH1A1 inhibitor (IC₅₀ = 40 nM). Exhibits >1000-fold selectivity for ALDH1A1 over ALDH3A1, ALDH1B1, ALDH2, HPGD and HSD17β4. Also selective over a panel of 168 GPCRs. Blood-brain barrier permeable.

化合物库 for NCT 501 hydrochloride

NCT 501 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for NCT 501 hydrochloride

分子量	452.98
公式	C₂₁H₃₂N₆O₃.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2080306-22-3
PubChem ID	124201852
InChI Key	MQNBJYUQFQUJQZ-UHFFFAOYSA-N
Smiles	CC(CCN1C(CN2CCN(C(C3CC3)=O)CC2)=NC4=C1C(N(C(N4C)=O)C)=O)C.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NCT 501 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	45.3	100
	DMSO	45.3	100

制备储备液 for NCT 501 hydrochloride

以下数据基于产品分子量 452.98。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.21 mL	11.04 mL	22.08 mL
5 mM	0.44 mL	2.21 mL	4.42 mL
10 mM	0.22 mL	1.1 mL	2.21 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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产品说明书 for NCT 501 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NCT 501 hydrochloride

参考文献是支持产品生物活性的出版物。

Yang et al (2015) Discovery of NCT-501, a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1). J.Med.Chem. 58 5967 PMID: 26207746

If you know of a relevant reference for NCT 501 hydrochloride, please let us know.

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1 篇 NCT 501 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NCT 501 hydrochloride 的部分引用包括：

Rui et al (2020) Phenotypic landscape of intestinal organoid regeneration. Nature 586 275-280 PMID: 33029001

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