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Submit ReviewNCX 4040
说明： NO-donating aspirin; anti-inflammatory and antitumor
化学名： 2-(Acetyloxy)benzoic acid 4-[(nitrooxy)methyl]phenyl ester
纯度： ≥98% (HPLC)
生物活性 for NCX 4040
NCX 4040 is a NO-donating aspirin; anti-inflammatory. Blocks inflammatory mediator production in isolated human monocytes (IC50 values are 0.07, 0.13, 0.15 and 0.18 μM for IL-1β, PGE2, IL-10 and TNF-α respectively). Decreases COX-2 expression (IC50 = 0.13 μM); disrupts proteasome-mediated degradation of iκB-α. Antiproliferative in HCT116 colon cancer cells; sensitizes drug-resistant ovarian tumor cells to cisplatin (Cat. No. 2251).
技术数据 for NCX 4040
| 分子量 | 331.28 |
| 公式 | C16H13NO7 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 287118-97-2 |
| PubChem ID | 9818919 |
| InChI Key | CTHNKWFUDCMLIQ-UHFFFAOYSA-N |
| Smiles | O=C(C)OC1=C(C(OC2=CC=C(CO[N+]([O-])=O)C=C2)=O)C=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NCX 4040
参考文献 for NCX 4040
参考文献是支持产品生物活性的出版物。
Ricciotti et al (2010) NCX 4040, a nitric oxide-donating aspirin, exerts anti-inflammatory effects through inhibition of I kappa B-alpha degradation in human monocytes. J.Immunol. 184 2140 PMID: 20065114
Yamakawa et al (2008) Growth inhibition of human colon cancer cell line HCT116 by bis[2-(acylamino)phenyl] disulfide and its action mechanism. Biol.Pharm.Bull. 31 916 PMID: 18451518
Bratasz et al (2008) NCX-4040, a nitric oxide-releasing aspirin, sensitizes drug-resistant human ovarian xenograft tumors to cisp. by depletion of cellular thiols. J.Transl.Med. 6 9 PMID: 18302761
Gao et al (2008) Immunomodulatory activity of synthetic triterpenoids: inhibition of lymphocyte proliferation, cell-mediated cytotoxicity, and cytokine gene expression through suppression of NF-κB. Immunopharmacol.Immunotoxicol. 30 581 PMID: 18608528
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关键词: NCX 4040, NCX 4040 supplier, NCX4040, NO, nitric, oxide, donating, donors, aspirin, para, cyclooxygenase, inhibitors, inhibits, anti-inflammatory, inflammation, NSAIDs, antitumor, cisplatin, resistant, Cyclooxygenase, Donors, /, Precursors, 4531, Tocris Bioscience
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