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NDT 9513727

Cat. No. 3333 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent, selective human C5a receptor negative allosteric modulator (NAM)
化学名： N,N-Bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-Imidazole-5-methanamine
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NDT 9513727

NDT 9513727 is a potent C5a receptor (C5aR) negative allosteric modulator (NAM) (IC50 = 11.6 nM); selective for human C5aR (IC50 values for rat and mouse C5aR are > 10 μM). Exhibits inverse agonist pharmacokinetics. Blocks degranulation response in C5a-stimulated U937 cells (IC50 = 7.1 nM). Exhibits selectivity for primate and gerbil receptor over other species. Orally bioavailable.

化合物库 for NDT 9513727

NDT 9513727 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for NDT 9513727

分子量 573.68
公式 C36H35N3O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 439571-48-9
PubChem ID 10210160
InChI Key ITACCRHKSPSKKL-UHFFFAOYSA-N
Smiles CCCCN1C(C6=CC=CC=C6)=NC(C7=CC=CC=C7)=C1CN(CC3=CC(OCO5)=C5C=C3)CC2=CC=C(OCO4)C4=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NDT 9513727

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 57.37 100
ethanol 57.37 100

制备储备液 for NDT 9513727

以下数据基于产品分子量 573.68。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.74 mL 8.72 mL 17.43 mL
5 mM 0.35 mL 1.74 mL 3.49 mL
10 mM 0.17 mL 0.87 mL 1.74 mL
50 mM 0.03 mL 0.17 mL 0.35 mL

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产品说明书 for NDT 9513727

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for NDT 9513727

参考文献是支持产品生物活性的出版物。

Brodbeck et al (2008) Identification and characterization of NDT 9513727 [N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-imidazole-5-methanamine], a novel, orally bioavailable C5a receptor inverse agonist. J.Pharmacol.Exp.Ther. 327 898 PMID: 18753409

Robertson (2018) Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727. Nature 553 111 PMID: 29300009

If you know of a relevant reference for NDT 9513727, please let us know.

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关键词: NDT 9513727, NDT 9513727 supplier, potent, complement, C5a, receptor, C5aR, antagonists, competitive, inverse, agonists, human, orally, active, NDT9513727, NAM, negative, allostreic, modulators, Complement, 3333, Tocris Bioscience

1 篇 NDT 9513727 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NDT 9513727 的部分引用包括：

Liu (2018) Orthosteric and allosteric action of the C5a receptor antagonists. Nat Struct Mol Biol 25 472 PMID: 29867214

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