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NE 100 hydrochloride

Cat. No. 3133 8 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective σ1 antagonist
化学名： 4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (8)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NE 100 hydrochloride

NE 100 hydrochloride is a potent and selective σ1 receptor antagonist (Ki = 0.86 nM) that displays > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, D2, 5-HT1A, 5-HT2 and PCP receptors. Exhibits reversible binding (Kd = 1.2 nM) and displays antipsychotic activity in vivo. Orally active.

化合物库 for NE 100 hydrochloride

NE 100 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for NE 100 hydrochloride

分子量 391.97
公式 C23H33NO2.HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 149409-57-4
PubChem ID 9952420
InChI Key ZHGMDXSHODHWHV-UHFFFAOYSA-N
Smiles CCCN(CCC)CCC1=CC=C(OC)C(OCCC2=CC=CC=C2)=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NE 100 hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 1.96 5
DMSO 39.2 100

制备储备液 for NE 100 hydrochloride

以下数据基于产品分子量 391.97。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.76 mL 25.51 mL
5 mM 0.51 mL 2.55 mL 5.1 mL
10 mM 0.26 mL 1.28 mL 2.55 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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产品说明书 for NE 100 hydrochloride

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for NE 100 hydrochloride

参考文献是支持产品生物活性的出版物。

Chaki et al (1994) NE-100, a novel potent σ ligand, preferentially binds to σ1 binding sites in guinea pig brain. Eur.J.Pharmacol. 251 R1 PMID: 8137864

Okuyama et al (1993) NE-100, a novel sigma receptor ligand: in vivo tests. Pharmacol.Letts. 53 PL285

Tanaka et al (1995) Characteristics of binding of [3H]NE-100, a novel sigma-receptor ligand, to guinea-pig brain membranes. Naunyn Schmied.Arch.Pharmacol. 351 244

If you know of a relevant reference for NE 100 hydrochloride, please let us know.

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关键词: NE 100 hydrochloride, NE 100 hydrochloride supplier, Selective, σ1, sigma1, antagonists, Receptors, NE100, Sigma1, 3133, Tocris Bioscience

8 篇 NE 100 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NE 100 hydrochloride 的部分引用包括：

Rodríguez-Muñoz et al (2015) The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders. Br J Pharmacol 6 35458 PMID: 26461475

Malik et al (2015) The effects of σ (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice. Int J Neuropsychopharmacol 172 2519 PMID: 25573298

Song et al (2022) Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome. Nat.Card.Res. 1 142 PMID: 36051854

Morató et al (2023) Development of a novel σ1 receptor biosensor based on its heterodimerization with binding immunoglobulin protein in living cells. ACS Chem.Neurosci. PMID: 37191585

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NE 100 hydrochloride 的评论

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It can inhibit sigma1 receptor.
By Yuyang Sun on 06/29/2022
分析类型： In Vitro
种属： Human
细胞系/组织： sh-sy5y

Used it to inhibit sigma 1 receptors. It can inhibit sigma 1 receptor and increase SOCE channels.

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