Nebivolol hydrochloride

Cat. No. 3517 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Highly selective β₁-adrenoceptor antagonist

化学名： (±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)

纯度： ≥98% (HPLC)

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Nebivolol hydrochloride

Nebivolol hydrochloride is a highly selective β₁-adrenoceptor antagonist (K_i values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at β₁, 5-HT_1A, β₂, 5-HT₂, α₁, H₁ and D₂ receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC₅₀ = 11.36 μM in renal arteries) and displays antihypertensive activity in vivo. GRK/β -arrestin biased agonist at the β2 adrenoceptor.

化合物库 for Nebivolol hydrochloride

Nebivolol hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Nebivolol hydrochloride

分子量	441.9
公式	C₂₂H₂₅F₂NO₄.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	152520-56-4
PubChem ID	11812257
InChI Key	JWEXHQAEWHKGCW-VCVZPGOSSA-N
Smiles	FC(C=C4)=CC3=C4O[C@@](CC3)([H])[C@H](O)CNC[C@@H](O)[C@]2([H])CCC1=CC(F)=CC=C1O2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Nebivolol hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	44.19	100
	ethanol	4.42	10

制备储备液 for Nebivolol hydrochloride

以下数据基于产品分子量 441.9。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.31 mL	22.63 mL
5 mM	0.45 mL	2.26 mL	4.53 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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产品说明书 for Nebivolol hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Nebivolol hydrochloride

参考文献是支持产品生物活性的出版物。

Pauwels et al (1988) The receptor binding profile of the new antihypertensive agent nebi. and its stereoisomers compared with various β-adrenergic blockers. Mol.Pharmacol. 34 843 PMID: 2462161

Georgescu et al (2008) Nebivolol induces a hyperpolarizing effect on smooth muscle cells in the mouse renal artery by activation of beta-2-adrenoceptors. Pharmacology 81 110 PMID: 17952013

Erickson et al (2013) The beta -blocker nebi. Is a GRK/ beta -arrestin biased agonist. PLoS One 8 e71980 PMID: 23977191

If you know of a relevant reference for Nebivolol hydrochloride, please let us know.

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关键词: Nebivolol hydrochloride, Nebivolol hydrochloride supplier, selective, α1-adrenoceptor, beta1-adrenoceptor, b1-adrenoceptor, b1-adrenergic, antagonists, β1-Adrenergic, beta1-Adrenergic, Receptors, Adrenergic, Beta-1, 3517, Tocris Bioscience

1 篇 Nebivolol hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Nebivolol hydrochloride 的部分引用包括：

Littmann et al (2015) Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. Brain Res 355 183 PMID: 26306764

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