NECA

Name: NECA
Brand: Tocris Bioscience
SKU: 1691
Rating: 4.5 (2 reviews)

Cat. No. 1691 24 篇引用文献 2 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： High affinity adenosine agonist

别名： 5'-N-Ethylcarboxamidoadenosine

化学名： 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide

纯度： ≥98% (HPLC)

说明书

引用文献 (24)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for NECA

NECA is a high affinity adenosine receptor agonist (K_i values are 6.2, 14, and 20 nM for human A₃, A₁ and A_2A receptors respectively; EC₅₀ = 2.4 μM for human A_2B). Inhibits platelet aggregation and is centrally active in vivo.

化合物库 for NECA

NECA is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for NECA

分子量	308.3
公式	C₁₂H₁₆N₆O₄
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	35920-39-9
PubChem ID	448222
InChI Key	JADDQZYHOWSFJD-FLNNQWSLSA-N
Smiles	O[C@@H]1[C@@H]([C@](NCC)=O)O[C@@H](N2C=NC3=C2N=CN=C3N)[C@@H]1O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NECA

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	12.33	40

制备储备液 for NECA

以下数据基于产品分子量 308.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.4 mM	8.11 mL	40.54 mL	81.09 mL
2 mM	1.62 mL	8.11 mL	16.22 mL
4 mM	0.81 mL	4.05 mL	8.11 mL
20 mM	0.16 mL	0.81 mL	1.62 mL

Molarity Calculator

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Reconstitution Calculator

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产品说明书 for NECA

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NECA

参考文献是支持产品生物活性的出版物。

Cusack and Hourani (1981) 5'-N-ethylcarboxamidoadenosine: a potent inhibitor of human platelet aggregation. Br.J.Pharmacol. 72 443 PMID: 7260485

Klotz (2000) Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 362 382 PMID: 11111832

Knapp et al (2001) Adenosine agonists CGS21680 and NECA inhibit the initiation of cocaine self-administration. Pharmacol.Biochem.Behav. 68 797 PMID: 11526979

If you know of a relevant reference for NECA, please let us know.

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关键词: NECA, NECA supplier, adenosines, receptor, agonists, Non-Selective, Receptors, 5-N-Ethylcarboxamidoadenosine, 5'-N-Ethylcarboxamidoadenosine, Non-selective, Adenosine, 1691, Tocris Bioscience