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Necrostatin-1

Cat. No. 2324 4 篇引用文献 2 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： RIP1 kinase inhibitor; inhibits necroptosis
化学名： 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
纯度： ≥98% (HPLC)
说明书
引用文献 (4)
评论 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Necrostatin-1

Necrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.

化合物库 for Necrostatin-1

Necrostatin-1 is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Necrostatin-1

分子量 259.33
公式 C13H13N3OS
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 4311-88-0
PubChem ID 2828334
InChI Key TXUWMXQFNYDOEZ-UHFFFAOYSA-N
Smiles CN1C(=S)NC(CC2=CNC3=CC=CC=C23)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Necrostatin-1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 7.78 30

制备储备液 for Necrostatin-1

以下数据基于产品分子量 259.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.3 mM 12.85 mL 64.27 mL 128.54 mL
1.5 mM 2.57 mL 12.85 mL 25.71 mL
3 mM 1.29 mL 6.43 mL 12.85 mL
15 mM 0.26 mL 1.29 mL 2.57 mL

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产品说明书 for Necrostatin-1

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Necrostatin-1

参考文献是支持产品生物活性的出版物。

Degterev et al (2005) Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat.Chem.Biol. 1 112 PMID: 16408008

Degterev et al (2008) Identification of RIP1 kinase as a specific cellular target of necroSTAT. Nat.Chem.Biol. 4 313 PMID: 18408713

Linkermann et al (2012) Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury. 81 751 PMID: 22237751

If you know of a relevant reference for Necrostatin-1, please let us know.

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关键词: Necrostatin-1, Necrostatin-1 supplier, non-apoptotic, cell, death, necroptosis, Death, domain, receptor-associated, adaptor, RIP1, inhibits, inhibitors, Apoptosis, RIPK, RIPK1, receptor-interacting, protein, kinase, 1, other, kinases, Necroptosis, RIP, Kinases, 2324, Tocris Bioscience

4 篇 Necrostatin-1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Necrostatin-1 的部分引用包括：

Greer et al (2018) ONC201 kills breast cancer cells in vitro by targeting mitochondria. Oncotarget 9 18454 PMID: 29719618

Chefetz et al (2019) A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Rep 26 3061 PMID: 30865894

Kim (2017) Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells Journal of Translational Medicine 15 123 PMID: 28569199

Sagher et al (2014) The small molecule NSC676914A is cytotoxic and differentially affects NFκB signaling in ovarian cancer cells and HEK293 cells. Cancer Cell Int 14 75 PMID: 25324692

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Necrostatin-1 的评论

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Necroptosis-related studies.
By MARINA KOUTSIOUMPA on 10/13/2022
分析类型： In Vitro
种属： Human

Combinatorial treatments of Necrostatin-1 with other chemotherapeutic drugs were performed to elucidate the dependance of the latter on the induction of necroptosis. Results were consistent.

good necroptosis inhibitor.
By Anonymous on 06/28/2020
分析类型： In Vitro
种属： Human
细胞系/组织： Caco-2

100nM of Nec-1 was used to inhibit RIPK1 after administration cells with TNFa, zVADfmk, and smac inhibitors to induce necroptosis, then cell death rate was measured with a commercial kit.

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