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Submit ReviewNed K
Discontinued Product
5976 has been discontinued.
View all General Calcium Signaling Agents products.
说明： Prevents Ca2+ oscillations in cardiomyocytes during ischemia/reperfusion; NAADP signaling inhibitor
化学名： (1R,3S)-1-[3-[[4-(2-Cyanophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
纯度： ≥98% (HPLC)
生物活性 for Ned K
Ned K is a NAADP inhibitor. Prevents Ca2+ oscillations in rat cardiomyocytes in vitro during simulated ischemia and reperfusion, but exhibits no significant effect on Ca2+ sparks. Significantly reduces infarct size in rat cardiac ischemia/reperfusion model in vivo.
技术数据 for Ned K
| 分子量 | 521.61 |
| 公式 | C31H31N5O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2250019-90-8 |
| PubChem ID | 127021041 |
| InChI Key | LMTWTJMBOFXQTH-LITSAYRRSA-N |
| Smiles | O=C(O)[C@H]1N[C@H](C2=CC=C(OC)C(CN3CCN(C4=CC=CC=C4C#N)CC3)=C2)C5=C(C(C=CC=C6)=C6N5)C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Ned K
参考文献 for Ned K
参考文献是支持产品生物活性的出版物。
Davidson et al (2015) Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore. Cardiovasc.Res. 108 357 PMID: 26395965
关键词: Ned K, Ned K supplier, Nedk, NAADP, signaling, inhibitors, inhibits, nicotinic, acid, adenine, dinucleotide, phosphate, cardioprotectant, calcium, Ca2+, General, Calcium, Signaling, Agents, 5976, Tocris Bioscience
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