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Ned K

Cat. No. 5976 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Prevents Ca2+ oscillations in cardiomyocytes during ischemia/reperfusion; NAADP signaling inhibitor
化学名： (1R,3S)-1-[3-[[4-(2-Cyanophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ned K

Ned K is a NAADP inhibitor. Prevents Ca2+ oscillations in rat cardiomyocytes in vitro during simulated ischemia and reperfusion, but exhibits no significant effect on Ca2+ sparks. Significantly reduces infarct size in rat cardiac ischemia/reperfusion model in vivo.

技术数据 for Ned K

分子量 521.61
公式 C31H31N5O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2250019-90-8
PubChem ID 127021041
InChI Key LMTWTJMBOFXQTH-LITSAYRRSA-N
Smiles O=C(O)[C@H]1N[C@H](C2=CC=C(OC)C(CN3CCN(C4=CC=CC=C4C#N)CC3)=C2)C5=C(C(C=CC=C6)=C6N5)C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ned K

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 26.08 50

制备储备液 for Ned K

以下数据基于产品分子量 521.61。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 3.83 mL 19.17 mL 38.34 mL
2.5 mM 0.77 mL 3.83 mL 7.67 mL
5 mM 0.38 mL 1.92 mL 3.83 mL
25 mM 0.08 mL 0.38 mL 0.77 mL

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参考文献 for Ned K

参考文献是支持产品生物活性的出版物。

Davidson et al (2015) Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore. Cardiovasc.Res. 108 357 PMID: 26395965

If you know of a relevant reference for Ned K, please let us know.

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关键词: Ned K, Ned K supplier, Nedk, NAADP, signaling, inhibitors, inhibits, nicotinic, acid, adenine, dinucleotide, phosphate, cardioprotectant, calcium, Ca2+, General, Calcium, Signaling, Agents, 5976, Tocris Bioscience

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