Netilmicin sulfate

Name: Netilmicin sulfate
Brand: Tocris Bioscience
SKU: 6339

Cat. No. 6339 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6339 has been discontinued.

View all HIV products.

说明： Inhibits HIV-1 viral replication by blocking TAR-tat interaction

化学名： O-3-Deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1-4)]-2-deoxy-N¹-ethyl-D-streptamine sestersulfate

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for Netilmicin sulfate

Binds the transactivation response element (TAR) of HIV-1 (K_d = 1.35 μM) and inhibits its interaction with Tat. Exhibits >35-fold selectivity for HIV-1 TAR over HIV-2 TAR or A-site and RRE RNA. Inhibits Tat-mediated HIV-1 activation and replication in T-cells in vitro. Also semisynthetic aminoglycoside antibiotic.

技术数据 for Netilmicin sulfate

分子量	720.78
公式	C₂₁H₄₁N₅O₇.2.5H₂SO₄
储存	Desiccate at RT
CAS Number	56391-57-2
PubChem ID	62115
InChI Key	AGFWIZQEWFGATK-UNZHCMSXSA-N
Smiles	OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.[H][C@@]1(OC(CN)=CC[C@H]1N)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@]3(OC[C@](O)([C@@H]([C@H]3O)NC)C)[H])NCC)N.[H][C@@]4(OC(CN)=CC[C@H]4N)O[C@@H]5[C@H](C[C@H]([C@@H]([C@H]5O)O[C@]6(OC[C@](O)([C@@H]([C@H]6O)NC)C)[H])NCC)N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Netilmicin sulfate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Netilmicin sulfate

参考文献是支持产品生物活性的出版物。

Stelzer et al (2011) Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble. Nat.Chem.Biol. 7 553 PMID: 21706033

Connelly et al (2016) The emerging role of RNA as a therapeutic target for small molecules. Cell.Chem.Biol. 23 1077 PMID: 27593111

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关键词: Netilmicin sulfate, Netilmicin sulfate supplier, HIV-1, transactivation, response, element, TAR, Tat, inhibitors, inhibits, semisynthetic, aminoglycoside, antibiotic, Antibiotics, Other, Transcription, Factors, HIV, 6339, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Netilmicin sulfate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

篇 Netilmicin sulfate 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Netilmicin sulfate 的引用文献。