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Submit ReviewNeuropeptide S (Mouse) is a potent endogenous neuropeptide S receptor (NPSR) agonist (EC50 = 3 nM). Induces mobilization of intracellular Ca2+. Increases locomotor activity and wakefulness in mice. Also reduces anxiety-like behavior in mice.
分子量 | 2182.47 |
公式 | C93H156N34O27 |
序列 | SFRNGVGSGAKKTSFRRAKQ |
储存 | Store at -20°C |
纯度 | ≥95% (HPLC) |
CAS Number | 412938-74-0 |
PubChem ID | 54581309 |
InChI Key | XBNIXBCJICZFRR-GYDKITGDSA-N |
Smiles | [H]N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性 | Soluble to 2 mg/ml in water |
参考文献是支持产品生物活性的出版物。
Xu et al (2004) Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. Neuron 43 487 PMID: 15312648
If you know of a relevant reference for Neuropeptide S (Mouse), please let us know.
关键词: Neuropeptide S (Mouse), Neuropeptide S (Mouse) supplier, Endogenous, neuropeptide, S, receptor, NPSR, agonists, agonism, wakefulness, arousal, anxiety, potent, anxiolytic, Neuropeptide, Receptors, 5857, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 Neuropeptide S (Mouse) 的部分引用包括:
Christopher R et al (2019) Mutant neuropeptide S receptor reduces sleep duration with preserved memory consolidation. Sci Transl Med 11 PMID: 31619542
Maya et al (2022) Familial natural short sleep mutations reduce Alzheimer pathology in mice. iScience 25 103964 PMID: 35496999
Dana et al (2021) Dissociative Effects of Neuropeptide S Receptor Deficiency and Nasal Neuropeptide S Administration on T-Maze Discrimination and Reversal Learning. Pharmaceuticals (Basel) 14 PMID: 34358069
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