NF 546

Name: NF 546
Brand: Tocris Bioscience
SKU: 3892
Rating: 4 (1 reviews)

Cat. No. 3892 5 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective P2Y₁₁ agonist

化学名： 4,4'-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)carbonylimino))-bis(1,3-xylene-alpha,alpha'-diphosphonic acid tetrasodium salt

纯度： ≥95% (HPLC)

说明书

引用文献 (5)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for NF 546

NF 546 is a P2Y₁₁ agonist (pEC₅₀ = 6.27). Exhibits selectivity for P2Y₁₁ over a range of P2Y and P2X receptors. Also inhibits DNA-binding activity of HMGA2 (IC₅₀ = 5.49 μM).

技术数据 for NF 546

分子量	1180.74
公式	C₄₇H₄₄N₆Na₄O₁₇P₄
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	1006028-37-0
PubChem ID	73755075
InChI Key	GSMUPMANKNAMAS-UHFFFAOYSA-J
Smiles	[Na+].[Na+].[Na+].[Na+].CC1=CC=C(C=C1NC(=O)C1=CC=CC(NC(=O)NC2=CC=CC(=C2)C(=O)NC2=C(C)C=CC(=C2)C(=O)NC2=CC=C(CP(O)([O-])=O)C=C2CP(O)([O-])=O)=C1)C(=O)NC1=C(CP(O)([O-])=O)C=C(CP(O)([O-])=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NF 546

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	11.81	10 温和加热

制备储备液 for NF 546

以下数据基于产品分子量 1180.74。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	8.47 mL	42.35 mL	84.69 mL
0.5 mM	1.69 mL	8.47 mL	16.94 mL
1 mM	0.85 mL	4.23 mL	8.47 mL
5 mM	0.17 mL	0.85 mL	1.69 mL

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产品说明书 for NF 546

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NF 546

参考文献是支持产品生物活性的出版物。

Meis et al (2010) NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-γ,γ'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleuk J.Pharmacol.Exp.Ther. 332 238 PMID: 19815812

Su et al (2020) Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays. Sci.Rep. 10 18850 PMID: 33139812

If you know of a relevant reference for NF 546, please let us know.

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关键词: NF 546, NF 546 supplier, NF546, p2y11, purinergic, receptors, agonists, agonism, HMGA2, inhibitors, inhibits, high, mobility, group, protein, AT-hook, 2, DNA, binding, Purinergic, P2Y, Receptors, 3892, Tocris Bioscience

5 篇 NF 546 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NF 546 的部分引用包括：

Johannes W et al (2019) A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia. Elife 8 PMID: 30821687

Su et al (2020) Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays. Sci Rep 10 18850 PMID: 33139812

Timothy S et al (2021) Differential Regulation of ATP- and UTP-Evoked Prostaglandin E2 and IL-6 Production from Human Airway Epithelial Cells. J Immunol 207 1275-1287 PMID: 34389624

Barragán-Iglesias et al (2014) Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells. Mol Pain 10 29 PMID: 24886406

Gao et al (2013) The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Sci Adv 9 31 PMID: 22825617

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Filter by:

Cell growth regulator.

By Anonymous on 06/10/2019

分析类型： In Vitro

种属： Human

细胞系/组织： H69

Used this compound in various concentrations (5-30 uM) to check the cell growth in H69 cells by InCucyte.

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.