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Submit ReviewNGD 94-1
说明： Selective D4 receptor ligand
化学名： 2-[4-[(2-Phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]-pyrimidine
纯度： ≥99% (HPLC)
生物活性 for NGD 94-1
High affinity D4 receptor ligand; selective over D1, D2, D3 and D5 receptors. Displays antagonist activity at the human D4.2 receptor (Ki = 3.6 nM in transfected CHO cells) and exhibits agonist activity at the D4.4 receptor in HEK 293 cells.
技术数据 for NGD 94-1
| 分子量 | 320.39 |
| 公式 | C18H20N6 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 178928-68-2 |
| PubChem ID | 188942 |
| InChI Key | OTVQCHUIPJYASM-UHFFFAOYSA-N |
| Smiles | C1(N2CCN(CC3=CN=C(C4=CC=CC=C4)N3)CC2)=NC=CC=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NGD 94-1
参考文献 for NGD 94-1
参考文献是支持产品生物活性的出版物。
Tallman et al (1997) I. NGD 94-1: Identification of a novel, high affinity antagonist at the human DA D4 receptor. J.Pharmacol.Exp.Ther. 282 1011 PMID: 9262370
Primus et al (1997) II. Localization and characterization of DA D4 binding sites in rat and human brain by use of the novel, D4 receptor-selective ligand [3H]NGD 94-1. J.Pharmacol.Exp.Ther. 282 1020 PMID: 9262371
Gazi et al (1999) NGD 94-1 as an agonist at human recombinant DA D4.4 receptors expressed in HEK293 cells. Eur.J.Pharmacol. 372 R9 PMID: 10395031
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关键词: NGD 94-1, NGD 94-1 supplier, NGD941, antagonist, dopamine, receptors, D4, D4.2, dopaminergic, ligand, receptor, Receptors, 3298, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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