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NIBR 189

Cat. No. 5203 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective EBI2 (GPR183) receptor antagonist
化学名： (2E)-3-(4-Bromophenyl)-1-[4-4-methoxybenzoyl)-1-piperazinyl]-2-propene-1-one
纯度： ≥99% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NIBR 189

NIBR 189 is a potent and selective EBI2 (GPR183) receptor antagonist (IC50 values are 11 and 15 nM for human and mouse EBI2 receptors respectively). Exhibits selectivity for EBI2 over a panel of other receptors, enzymes and transporters. Blocks oxysterol-induced migration of U937 monocyte cells. Orally bioavailable.

技术数据 for NIBR 189

分子量 429.31
公式 C21H21BrN2O3
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1599432-08-2
PubChem ID 36295259
InChI Key OFHXXBRBGWUOHR-NYYWCZLTSA-N
Smiles BrC1=CC=C(/C=C/C(N2CCN(C(C3=CC=C(OC)C=C3)=O)CC2)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NIBR 189

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 42.93 100

制备储备液 for NIBR 189

以下数据基于产品分子量 429.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.65 mL 23.29 mL
5 mM 0.47 mL 2.33 mL 4.66 mL
10 mM 0.23 mL 1.16 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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参考文献 for NIBR 189

参考文献是支持产品生物活性的出版物。

Gessier et al (2014) Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. J.Med.Chem. 57 3358 PMID: 24678947

If you know of a relevant reference for NIBR 189, please let us know.

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关键词: NIBR 189, NIBR 189 supplier, NIBR189, potent, selective, EBI2, GPR183, Epstein-bar, virus, induced, gene, 2, receptors, antagonists, orally, bioavailable, Orphan, 7-TM, Receptors, 5203, Tocris Bioscience

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