Nintedanib

Cat. No. 7049 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent VEGFR, PDGFR and FGFR inhibitor

化学名： Methyl (Z)-3-[[[4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene]-2-oxoindoline-6-carboxylate

纯度： ≥98%

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Nintedanib

Nintedanib is a potent inhibitor of vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs) and fibroblast growth factor receptors (FGFRs) (IC₅₀ values are 13 - 34 nM for VEGFR subtypes, 59 - 65 nM for PDGFR subtypes, 37 - 108 nM for FGFR subtypes). Also inhibits Flt-3, Lck, Lyn and Src (IC₅₀ values are 25 - 200 nM). Inhibits proliferation in VEGF-stimulated endothelial cells, and PDGF-stimulated pericytes and vascular smooth muscle cells. Reduces vessel density and integrity, and inhibits tumor growth in a mouse tumor xenograft model.

技术数据 for Nintedanib

分子量	539.64
公式	C₃₁H₃₃N₅O₄
储存	Store at -20°C
纯度	≥98%
CAS Number	656247-17-5
PubChem ID	135423438
InChI Key	XZXHXSATPCNXJR-ZIADKAODSA-N
Smiles	COC(=O)C1=CC=C2C(NC(=O)\C2=C(/NC2=CC=C(C=C2)N(C)C(=O)CN2CCN(C)CC2)C2=CC=CC=C2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Nintedanib

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	1.08	2 温和加热

制备储备液 for Nintedanib

以下数据基于产品分子量 539.64。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.02 mM	92.65 mL	463.27 mL	926.54 mL
0.1 mM	18.53 mL	92.65 mL	185.31 mL
0.2 mM	9.27 mL	46.33 mL	92.65 mL
1 mM	1.85 mL	9.27 mL	18.53 mL

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产品说明书 for Nintedanib

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Nintedanib

参考文献是支持产品生物活性的出版物。

Hilberg et al (2008) BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res. 68 4774 PMID: 18559524

If you know of a relevant reference for Nintedanib, please let us know.

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关键词: Nintedanib, Nintedanib supplier, BIBF1120, angiokinase, inhibitors, inhibits, VEGFR, PDGFR, FGFR, potent, vascular, endothelial, growth, factor, platelet-derived, fibroblast, angiogenesis, VEGF, FGF, PDGF, 7049, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for Nintedanib

VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.