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Nitazoxanide

Cat. No. 7234 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Pyruvate flavodoxin/ferredoxin oxidoreductase inhibitor; also inhibits Wnt signaling; broad spectrum anti-infective
化学名： 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Nitazoxanide

Nitazoxanide is a pyruvate flavodoxin/ferredoxin oxidoreductase (PFOR) inhibitor. Also inhibits Wnt signaling by stabilization of peptidyl arginine deiminase 2 (PAD2). Broad-spectrum antiparasitic and antiviral. Inhibits SARS-CoV-2 infection in Vero E6 cells (EC50 = 2.12μM).

化合物库 for Nitazoxanide

Nitazoxanide is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Nitazoxanide

分子量 307.28
公式 C12H9N3O5S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 55981-09-4
PubChem ID 41684
InChI Key YQNQNVDNTFHQSW-UHFFFAOYSA-N
Smiles CC(OC1=C(C(NC2=NC=C([N+]([O-])=O)S2)=O)C=CC=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Nitazoxanide

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.73 100

制备储备液 for Nitazoxanide

以下数据基于产品分子量 307.28。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.54 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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参考文献 for Nitazoxanide

参考文献是支持产品生物活性的出版物。

Shakya et al (2018) Update on Nitazoxanide: a multifunctional chemotherapeutic agent. Curr.Drug Discov.Technol. 15 201 PMID: 28748751

Wang et al (2020) Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 30 269 PMID: 32020029

Qu et al (2017) Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer. Nat.Chem.Biol. 14 94 PMID: 29083417

If you know of a relevant reference for Nitazoxanide, please let us know.

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关键词: Nitazoxanide, Nitazoxanide supplier, broad, spectrum, anti-infective, antiparasitic, antiviral, inhibitors, inhibits, pyruvate, flavodoxin/ferredoxin, oxidoreductase, PFOR, peptidyl, arginine, deiminase, 2, PADI2, PAD2, SARS-CoV-2, Wnt, signaling, Other, Oxygenases/Oxidases, Post-translational, Modifications, Signaling, Non-selective, Antivirals, Coronavirus, 7234, Tocris Bioscience

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