NKH 477

Cat. No. 1603 7 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Water-soluble adenylyl cyclase activator

别名： Colforsin dapropate hydrochloride,6-(3-dimethylaminopropionyl)forskolin hydrochloride

化学名： N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester β-alanine hydrochloride

纯度： ≥98% (HPLC)

引用文献 (7)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for NKH 477

NKH 477 is a water-soluble analog of forskolin (Cat. No. 1099) that is a potent activator of adenylyl cyclase; shows some selectivity for cardiac (type V) adenylyl cyclase. Stimulates bronchodilation (EC₅₀ = 32.6 nM) and is an orally active potent positive chronotrope and hypotensive agent in vivo.

技术数据 for NKH 477

分子量	546.1
公式	C₂₇H₄₃NO₈.HCl
储存	Desiccate at +4°C
纯度	≥98% (HPLC)
CAS Number	138605-00-2
PubChem ID	444028
InChI Key	VIRRLEDAYYYTOD-YHEOSNBFSA-N
Smiles	O=C(CCN(C)C)O[C@H]2[C@@]1([H])C(C)(C)CC[C@H](O)[C@@](C)1[C@]3(O)[C@@](O[C@](C=C)(C)CC3=O)(C)[C@H]2OC(C)=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NKH 477

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	21.84	40

制备储备液 for NKH 477

以下数据基于产品分子量 546.1。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.4 mM	4.58 mL	22.89 mL	45.78 mL
2 mM	0.92 mL	4.58 mL	9.16 mL
4 mM	0.46 mL	2.29 mL	4.58 mL
20 mM	0.09 mL	0.46 mL	0.92 mL

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产品说明书 for NKH 477

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NKH 477

参考文献是支持产品生物活性的出版物。

Hosono et al (1992) Cardiovascular and adenylate cyclase stimulant properties of NKH477, a novel water-soluble forskolin derivative. J.Cardiovasc.Pharmacol. 19 625 PMID: 1380607

Satake et al (1998) Relaxant effects of NKH477, a new water-soluble forskolin derivative, on guinea-pig tracheal smooth muscle: the role of Ca²⁺-activated K⁺ channels. Br.J.Pharmacol. 123 753 PMID: 9517396

Toya et al (1998) Forskolin derivatives with increased selectivity for cardiac adenylyl cyclase. J.Mol.Cell.Cardiol. 30 97 PMID: 9500868

If you know of a relevant reference for NKH 477, please let us know.

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关键词: NKH 477, NKH 477 supplier, Water-soluble, adenylyl, adenylate, cyclases, activators, cAMP, NKH477, Colforsin, dapropate, hydrochloride, 6-(3-dimethylaminopropionyl)forskolin, Adenylyl, Cyclase, Enzyme, Substrates, /, Activators, 1603, Tocris Bioscience