NLS-StAx-h

Cat. No. 6531 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Wnt signaling inhibitor; inhibits β-catenin-transcription factor interactions

纯度： ≥95% (HPLC)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for NLS-StAx-h

NLS-StAx-h is a Wnt inhibitor (IC₅₀ = 1.4 μM). Stapled peptide inhibitor of oncogenic Wnt signaling. Inhibits β-catenin-transcription factor interactions. Inhibits proliferation and migration of colorectal cancer cells. Cell permeable.

技术数据 for NLS-StAx-h

分子量	3445.26
公式	C₁₆₁H₂₇₅N₅₅O₂₉
序列	PKKKRKVRRWPRXILDXHVRRVWR (Modifications: Val-7 = Val-PEG2, Arg-8 = Arg-9 = Arg-12 = Arg-20 = Arg-21 = homo-Arg, X = (S)-2-(4-pentenyl)alanine, X-13 and X-17 stapled together with a double bond, Arg-24 = homo-Arg & C-terminal amide)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	2872559-21-0
InChI Key	NQDXIROEXUQMGO-YCYPXFDESA-N
Smiles	O=C([C@H]1NCCC1)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCCOCCOCC(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@@](CCC/C=C\CCC[C@](C)(NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCCCNC(N)=N)=O)CC4=CNC5=CC=CC=C45)=O)C(C)C)=O)CCCCNC(N)=N)=O)CCCCNC(N)=N)=O)C(C)C)=O)CC6=CNC=N6)=O)(C(N[C@H](C(N[C@H](C(N[C@H]3CC(O)=O)=O)CC(C)C)=O)[C@H](CC)C)=O)C)=O)CCCCNC(N)=N)=O)CCC2)=O)CC7=CNC8=CC=CC=C78)=O)CCCCNC(N)=N)=O)CCCCNC(N)=N)=O)=O)C(C)C)=O)CCCCN)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)CCCCN

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NLS-StAx-h

溶解性	Soluble to 1 mg/ml in water

产品说明书 for NLS-StAx-h

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NLS-StAx-h

参考文献是支持产品生物活性的出版物。

Dietrich et al (2017) Cell permeable stapled peptide inhibitor of Wnt signaling that targets β-catenin protein-protein Interactions. Cell Chem.Biol. 24 958 PMID: 28757184

If you know of a relevant reference for NLS-StAx-h, please let us know.

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关键词: NLS-StAx-h, NLS-StAx-h supplier, NLS, StAxh, StAx_h, Wnt, signaling, inhibitors, inhibits, beta, catenin, βcatenin, stapled, peptide, Beta-catenin, Stapled, Peptides, 6531, Tocris Bioscience

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Pathways for NLS-StAx-h

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.