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NNC 0640

Cat. No. 6807 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Negative allosteric modulator of glucagon and GLP-1 receptors
化学名： 4-[[(4-Cyclohexylphenyl)[[[3-(methylsulfonyl)phenyl]amino]carbonyl]amino]methyl]-N-2H-tetrazol-5-ylbenzamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NNC 0640

NNC 0640 is a negative allosteric modulator of glucagon receptors (pKi = 7.4). Binds to external surface of the transmembrane domain. Also negative allosteric modulator of glucagon-like peptide 1 (GLP-1) receptor. Inhibits GLP-1-mediated cAMP accumulation in vitro.

技术数据 for NNC 0640

分子量 573.67
公式 C29H31N7O4S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 307986-98-7
PubChem ID 23549991
InChI Key PPTKULJUDJWTSA-UHFFFAOYSA-N
Smiles CS(=O)(C1=CC=CC(NC(N(C2=CC=C(C3CCCCC3)C=C2)CC4=CC=C(C(NC5=NN=NN5)=O)C=C4)=O)=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NNC 0640

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 57.37 100

制备储备液 for NNC 0640

以下数据基于产品分子量 573.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.74 mL 8.72 mL 17.43 mL
5 mM 0.35 mL 1.74 mL 3.49 mL
10 mM 0.17 mL 0.87 mL 1.74 mL
50 mM 0.03 mL 0.17 mL 0.35 mL

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参考文献 for NNC 0640

参考文献是支持产品生物活性的出版物。

Zhang et al (2017) Structure of the full-length glucagon class B g-protein-coupled receptor. Nature. 546 259 PMID: 28514451

Jazayeri et al (2016) Extra-helical binding site of a glucagon receptor antagonist. Nature. 533 274 PMID: 27111510

Song et al (2017) Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature. 546 213 PMID: 28514449

If you know of a relevant reference for NNC 0640, please let us know.

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关键词: NNC 0640, NNC 0640 supplier, NNC0640, glucagon, receptor, glucagon-like, peptide, 1, GLP-1, GLP-1R, negative, allosteric, modulators, modulates, NAMs, GCGR, Glucagon, Receptor, Glucagon-Like, Peptide, Receptors, 6807, Tocris Bioscience

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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.