主页 / 药理学 / Ion Channels / Calcium Channels / Voltage-gated Calcium Channels (CaV) / CaV3.x Channels (T-type) / CaV3.x Channel (T-type) Blockers / NNC 55-0396 dihydrochloride

NNC 55-0396 dihydrochloride

Cat. No. 2268 9 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Highly selective CaV3.x blocker
化学名： (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl cyclopropanecarboxylate dihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (9)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NNC 55-0396 dihydrochloride

NNC 55-0396 dihydrochloride is a highly selective T-type calcium channel blocker. Displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.

技术数据 for NNC 55-0396 dihydrochloride

分子量 564.57
公式 C30H38FN3O2.2HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 357400-13-6
PubChem ID 22084904
InChI Key BCCQNBXHUMKLFW-HNQRYHMESA-N
Smiles FC1=CC(CC[C@@](CCN(C)CCCC3=NC(C=CC=C5)=C5N3)(OC(C4CC4)=O)[C@H]2[C@H](C)C)=C2C=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NNC 55-0396 dihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 14.11 25

制备储备液 for NNC 55-0396 dihydrochloride

以下数据基于产品分子量 564.57。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.25 mM 7.09 mL 35.43 mL 70.85 mL
1.25 mM 1.42 mL 7.09 mL 14.17 mL
2.5 mM 0.71 mL 3.54 mL 7.09 mL
12.5 mM 0.14 mL 0.71 mL 1.42 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for NNC 55-0396 dihydrochloride

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for NNC 55-0396 dihydrochloride

参考文献是支持产品生物活性的出版物。

Huang et al (2004) NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: A new selective inhibitor of T-type calcium cha J.Pharmacol.Exp.Ther. 309 193 PMID: 14718587

Chen et al (2010) CaV3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. J.Neurosci. 30 10360 PMID: 20685979

If you know of a relevant reference for NNC 55-0396 dihydrochloride, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 CaV3.x Channel (T-type) Blockers

关键词: NNC 55-0396 dihydrochloride, NNC 55-0396 dihydrochloride supplier, selective, Ca2+, channel, blockers, T-type, Calcium, CaV, Channels, T-Type, voltage-gated, voltage-dependent, NNC550396, dihydrochloride, Cav3.x, 2268, Tocris Bioscience

9 篇 NNC 55-0396 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NNC 55-0396 dihydrochloride 的部分引用包括：

Senadheera et al (2013) Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery. Proc Natl Acad Sci U S A 305 R917 PMID: 23948776

Goswami et al (2012) Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca2+ channels via microdomain coupling. J Neurosci 32 14294 PMID: 23055500

Schneider et al (2013) Calcium-based dendritic excitability and its regulation in the deep cerebellar nuclei. J Neurophysiol 109 2282 PMID: 23427305

Chen et al (2010) Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. J Neurosci 30 10360 PMID: 20685979

您是否知道使用了 Tocris NNC 55-0396 dihydrochloride 的优秀论文？ 请告知我们.

NNC 55-0396 dihydrochloride 的评论

目前没有该产品的评论。 Be the first to review NNC 55-0396 dihydrochloride and earn rewards!

Have you used NNC 55-0396 dihydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review