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Submit ReviewNNC 55-0396 dihydrochloride
说明： Highly selective CaV3.x blocker
化学名： (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl cyclopropanecarboxylate dihydrochloride
纯度： ≥98% (HPLC)
生物活性 for NNC 55-0396 dihydrochloride
NNC 55-0396 dihydrochloride is a highly selective T-type calcium channel blocker. Displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.
技术数据 for NNC 55-0396 dihydrochloride
| 分子量 | 564.57 |
| 公式 | C30H38FN3O2.2HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 357400-13-6 |
| PubChem ID | 22084904 |
| InChI Key | BCCQNBXHUMKLFW-HNQRYHMESA-N |
| Smiles | FC1=CC(CC[C@@](CCN(C)CCCC3=NC(C=CC=C5)=C5N3)(OC(C4CC4)=O)[C@H]2[C@H](C)C)=C2C=C1.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for NNC 55-0396 dihydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 14.11 | 25 |
制备储备液 for NNC 55-0396 dihydrochloride
以下数据基于产品分子量 564.57。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 7.09 mL | 35.43 mL | 70.85 mL |
| 1.25 mM | 1.42 mL | 7.09 mL | 14.17 mL |
| 2.5 mM | 0.71 mL | 3.54 mL | 7.09 mL |
| 12.5 mM | 0.14 mL | 0.71 mL | 1.42 mL |
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产品说明书 for NNC 55-0396 dihydrochloride
参考文献 for NNC 55-0396 dihydrochloride
参考文献是支持产品生物活性的出版物。
Huang et al (2004) NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: A new selective inhibitor of T-type calcium cha J.Pharmacol.Exp.Ther. 309 193 PMID: 14718587
Chen et al (2010) CaV3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. J.Neurosci. 30 10360 PMID: 20685979
If you know of a relevant reference for NNC 55-0396 dihydrochloride, please let us know.
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关键词: NNC 55-0396 dihydrochloride, NNC 55-0396 dihydrochloride supplier, selective, Ca2+, channel, blockers, T-type, Calcium, CaV, Channels, T-Type, voltage-gated, voltage-dependent, NNC550396, dihydrochloride, Cav3.x, 2268, Tocris Bioscience
9 篇 NNC 55-0396 dihydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NNC 55-0396 dihydrochloride 的部分引用包括：
Schneider et al (2013) Calcium-based dendritic excitability and its regulation in the deep cerebellar nuclei. J Neurophysiol 109 2282 PMID: 23427305
Tzeng et al (2012) The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice. Cardiovasc Res 96 533 PMID: 22886848
Kuo et al (2010) Dihydropyridine-insensitive calcium currents contribute to function of small cerebral arteries. J Cereb Blood Flow Metab 30 1226 PMID: 20125181
Chen et al (2010) Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. J Neurosci 30 10360 PMID: 20685979
Baillie et al (2012) Sumatriptan inhibition of N-type calcium channel mediated signaling in dural CGRP terminal fibres. Am J Physiol Regul Integr Comp Physiol 63 362 PMID: 22691374
Abe et al (2011) The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells. PLoS One 108 12497 PMID: 21746923
Senadheera et al (2013) Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery. Proc Natl Acad Sci U S A 305 R917 PMID: 23948776
Mundt et al (2018) TRPV4 is the temperature-sensitive ion channel of human sperm. Elife 7 PMID: 29963982
Goswami et al (2012) Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca2+ channels via microdomain coupling. J Neurosci 32 14294 PMID: 23055500
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