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Submit ReviewNNC 711
说明： Selective GAT-1 inhibitor
化学名： 1,2,5,6-Tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylic acid hydrochloride
纯度： ≥99% (HPLC)
生物活性 for NNC 711
NNC 711 is a potent and selective inhibitor of GABA uptake by GAT-1 (IC50 values are 0.04, 171, 1700 and 622 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Anticonvulsant following systemic administration in vivo. Also exhibits cognition-enhancing activity.
化合物库 for NNC 711
NNC 711 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for NNC 711
| 分子量 | 386.88 |
| 公式 | C21H22N2O3.HCl |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 145645-62-1 |
| PubChem ID | 123738 |
| InChI Key | YZYRTEYMUTWJPL-UHFFFAOYSA-N |
| Smiles | O=C(C1=CCCN(CCO/N=C(C3=CC=CC=C3)/C2=CC=CC=C2)C1)O.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for NNC 711
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 3.87 | 10 | |
| DMSO | 38.69 | 100 |
制备储备液 for NNC 711
以下数据基于产品分子量 386.88。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.58 mL | 12.92 mL | 25.85 mL |
| 5 mM | 0.52 mL | 2.58 mL | 5.17 mL |
| 10 mM | 0.26 mL | 1.29 mL | 2.58 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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产品说明书 for NNC 711
参考文献 for NNC 711
参考文献是支持产品生物活性的出版物。
Borden et al (1994) Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 269 219 PMID: 7851497
Suzdak et al (1992) NNC-711, a novel potent and selective γ-aminobutyric acid uptake inhibitor: pharmacological characterization. Eur.J.Pharmacol. 224 189 PMID: 1468507
O'Connell et al (2001) Anti-ischemic and cognition-enhancing properties of NNC-711, a γ-aminobutyric acid reuptake inhibitor. Eur.J.Pharmacol. 424 37 PMID: 11470258
If you know of a relevant reference for NNC 711, please let us know.
按产品操作查看相关产品
关键词: NNC 711, NNC 711 supplier, Selective, inhibitors, inhibits, GAT-1, GABA, Transporters, Monoamine, Neurotransmitter, NNC711, 1779, Tocris Bioscience
4 篇 NNC 711 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NNC 711 的部分引用包括：
Yoshizumi et al (2012) Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats. Pain 116 1347 PMID: 22487864
Kersanté et al (2013) A functional role for both -aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus. Anesthesiology 591 2429 PMID: 23381899
Samoudi et al (2012) Noisy galvanic vestibular stimulation promotes GABA release in the substantia nigra and improves locomotion in hemiparkinsonian rats. PLoS One 7 e29308 PMID: 22238601
Héja et al (2009) Glutamate uptake triggers transporter-mediated GABA release from astrocytes. J Physiol 4 e7153 PMID: 19777062
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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