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NNMTi

Cat. No. 6900 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Nicotinamide N-methyltransferase (NNMT) inhibitor; promotes myoblast differentiation
化学名： 5-Amino-1-methylquinolinium iodide
纯度： ≥97% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NNMTi

NNMTi is a nicotinamide N-methyltransferase (NNMT) inhibitor (IC50 = 1.2 μM). Promotes myoblast differentiation in C2C12 cells. Activates senescent muscle stem cells (muSCs) and improves regenerative capacity of aged skeletal muscle. Enhances proliferation, fusion and regenerative capacity of muSCs in aged mice.

技术数据 for NNMTi

分子量 286.11
公式 C10H11IN2
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 42464-96-0
PubChem ID 66522933
InChI Key JPEZFBFIRRAFNR-UHFFFAOYSA-N
Smiles [I-].C[N+]1=CC=CC2=C(N)C=CC=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NNMTi

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 28.61 100

制备储备液 for NNMTi

以下数据基于产品分子量 286.11。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.5 mL 17.48 mL 34.95 mL
5 mM 0.7 mL 3.5 mL 6.99 mL
10 mM 0.35 mL 1.75 mL 3.5 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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参考文献 for NNMTi

参考文献是支持产品生物活性的出版物。

Neelakantan et al (2019) Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem. Pharmacol. 163 481 PMID: 30753815

Neelakantan et al (2017) Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase. J.Med.Chem. 60 5015 PMID: 28548833

If you know of a relevant reference for NNMTi, please let us know.

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关键词: NNMTi, NNMTi supplier, Nicotinamide, N, Methyltransferase, NNMT, inhibitors, inhibits, myoblast, differentiation, muscle, stem, cells, aged, Other, Transferases, Differentiation, Products, 6900, Tocris Bioscience

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