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说明： Endogenous agonist for CB1 and GPR55
别名： HU 310,2-Arachidonyl glycerol ether
化学名： 2-[(5Z,8Z,11Z,14Z)-Eicosatetraenyloxy]-1,3-propanediol
生物活性 for Noladin ether
Noladin ether is an endogenous agonist for the GPR55 and CB1 receptors (EC50 values are 10 and 37 nM respectively) that displays selectivity over CB2 receptors (Ki values are 21.2 nM and > 3mM at CB1 and CB2 respectively). Causes sedation, hypothermia, intestinal immobility and mild antinociception in vivo. Attenuates sensory neurotransmission in rat mesenteric arteries via GPR55.
技术数据 for Noladin ether
| 分子量 | 364.57 |
| 公式 | C23H40O3 |
| 储存 | Desiccate at -20°C |
| CAS Number | 222723-55-9 |
| PubChem ID | 6483057 |
| InChI Key | CUJUUWXZAQHCNC-DOFZRALJSA-N |
| Smiles | CCCCC\C=C/C\C=C/C/C=C\C/C=C\CCCCOC(CO)CO |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Noladin ether
参考文献 for Noladin ether
参考文献是支持产品生物活性的出版物。
Duncan et al (2004) Noladin ether, a putative endocannabinoid, attenuates sensory neurotransmission in the rat isolated mesenteric arterial bed via a non-CB1/CB2 Gi/o linked receptor. Br.J.Pharmacol. 142 509 PMID: 15148262
Hanus et al (2001) 2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor. Proc.Natl.Acad.Sci.U.S.A. 98 3662 PMID: 11259648
Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092 PMID: 17876302
Sugiura et al (1999) Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. J.Biol.Chem. 274 2794 PMID: 9915812
Suhara et al (2000) Synthesis and biological activities of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, and its metabolically stable ether-linked analogues. Chem.Pharm.Bull. 48 903 PMID: 10923815
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关键词: Noladin ether, Noladin ether supplier, Endogenous, agonists, GPR55, CB1, Cannabinoids, Receptors, HU310, cb1r, HU, 310, 2-Arachidonyl, glycerol, ether, 1411, Tocris Bioscience
1 篇 Noladin ether 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Noladin ether 的部分引用包括：
Ho and Randall (2007) Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. PLoS One 150 641 PMID: 17245358
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