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Submit ReviewNomifensine
说明： Potent noradrenalin and dopamine uptake inhibitor. Antidepressant
化学名： 1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine maleate
纯度： ≥98% (HPLC)
生物活性 for Nomifensine
Nomifensine is a potent inhibitor of noradrenaline and dopamine uptake (Ki values are 4.7, 26 and 4000 nM for inhibition of noradrenaline, dopamine and 5-HT uptake respectively, in rat brain). Increases central dopamine levels in rats following systemic administration. Displays antidepressant activity.
技术数据 for Nomifensine
| 分子量 | 354.4 |
| 公式 | C16H18N2.C4H4O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 32795-47-4 |
| PubChem ID | 5358907 |
| InChI Key | GEOCVSMCLVIOEV-BTJKTKAUSA-N |
| Smiles | NC1=CC=CC2=C1C[N+]([H])(C)CC2C3=CC=CC=C3.O=C(O)\C=C/C([O-])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Nomifensine
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 35.44 | 100 |
制备储备液 for Nomifensine
以下数据基于产品分子量 354.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.82 mL | 14.11 mL | 28.22 mL |
| 5 mM | 0.56 mL | 2.82 mL | 5.64 mL |
| 10 mM | 0.28 mL | 1.41 mL | 2.82 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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产品说明书 for Nomifensine
参考文献 for Nomifensine
参考文献是支持产品生物活性的出版物。
Tuomisto (1977) Nomifensine and its derivatives as possible tools for studying amine uptake. Eur.J.Pharmacol. 42 101 PMID: 844493
Nakachi et al (1995) Effects of various DA uptake inhibitors on striatal extracellular DA levels and behaviours in rats. Eur.J.Pharmacol. 281 195 PMID: 7589207
Katz et al (2010) Effects of acute and sustained administration of the catecholamine reuptake inhibitor nomifensine on the firing activity of monoaminergic neurons. J.Psychopharmacol. 24 1223 PMID: 19939862
If you know of a relevant reference for Nomifensine, please let us know.
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关键词: Nomifensine, Nomifensine supplier, noradrenaline, noradrenalin, norepinephrine, NET, DAT, transporter, transports, dopamine, reuptake, uptake, inhibitors, inhibits, antidepressants, anti-depressants, depression, Adrenergic, Transporters, Dopamine, 1992, Tocris Bioscience
1 篇 Nomifensine 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Nomifensine 的部分引用包括：
Zapata et al (2007) Regulation of DA transporter function and cell surface expression by D3 DA receptors. J Biol Chem 282 35842 PMID: 17923483
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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