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Submit ReviewNovokinin
Discontinued Product
3615 has been discontinued.
View all Angiotensin AT<sub>2</sub> Receptors products.
说明： AT2 agonist; orally active
生物活性 for Novokinin
Novokinin is an angiotensin AT2 receptor agonist (Ki = 7.35 μM) that displays 93-fold selectivity over AT1. Exhibits vasorelaxing and hypotensive activity via activation of the IP (prostacyclin) receptor, and suppresses food intake via activation of PGE2-EP4. Orally active.
技术数据 for Novokinin
| 分子量 | 795.98 |
| 公式 | C39H61N11O7 |
| 序列 | RPLKPW |
| 储存 | Desiccate at -20°C |
| CAS Number | 358738-77-9 |
| PubChem ID | 9987879 |
| InChI Key | WCJSVACAALWGRF-LQPYQXOBSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Novokinin
参考文献 for Novokinin
参考文献是支持产品生物活性的出版物。
Yamada et al (2008) A potent hypotensive peptide, novokinin, induces relaxation by AT2- and IP-receptor-dependent mechanism in the mesenteric artery from SHRs. Biosci.Biotechnol.Biochem. 72 257 PMID: 18175894
Yamada et al (2008) Hypotensive activity of novokinin, a potent analogue of ovokinin(2-7), is mediated by angiotensin AT2 receptor and prostaglandin IP receptor. Peptides 29 412 PMID: 18207609
Ohinata et al (2009) Orally administered novokinin, an angiotensin AT2 receptor agonist, suppresses food intake via prostaglandin E2-dependent mechanism in mice. Peptides 30 1105 PMID: 19463743
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关键词: Novokinin, Novokinin supplier, Orally, active, agonists, Angiotensin, Receptors, AT2, 3615, Tocris Bioscience
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