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说明： Potent and selective NADPH oxidase 1 (NOX1) inhibitor
生物活性 for NoxA1ds
NoxA1ds is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. Cell permeable.
技术数据 for NoxA1ds
| 分子量 | 1125.33 |
| 公式 | C50H88N14O15 |
| 序列 |
EPVDALGKAKV (Modifications: Val-11 = C-terminal amide) |
| 储存 | Store at -20°C |
| CAS Number | 1435893-78-9 |
| PubChem ID | 121513898 |
| InChI Key | DHBOJLLJKHKZGT-XTGVMIFDSA-N |
| Smiles | [H]N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NoxA1ds
参考文献 for NoxA1ds
参考文献是支持产品生物活性的出版物。
Ranayhossaini et al (2013) Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration. J.Biol.Chem. 288 36437 PMID: 24187133
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关键词: NoxA1ds, NoxA1ds supplier, NADPH, oxidases, NOX1, inhibitors, inhibits, hypoxia, ROS, reactive, oxygen, species, Oxidase, 5848, Tocris Bioscience
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