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NADPH Oxidase

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases are multi-subunit enzyme complexes that transfer electrons across biological membranes and catalyze the production of reactive oxygen species (ROS).

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Gene Data

NADPH Oxidase Inhibitors
Cat. No. 产品名称/活性
4663 Apocynin
NADPH-oxidase inhibitor
0504 Diphenyleneiodonium chloride
Inhibits NADPH oxidases; also inhibits NOS
6848 GSK 2795039
NADPH oxidase 2 (NOX2) inhibitor
6654 VAS 2870
NADPH oxidase (Nox) inhibitor

Other
Cat. No. 产品名称/活性
5515 NADPH reduced form tetrasodium salt
Cofactor for many anabolic enzymes

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases are multi-subunit enzyme complexes that transfer electrons across biological membranes and catalyze the production of reactive oxygen species (ROS). NADPH oxidases use NADPH as an electron donor in the reduction of molecular oxygen to form superoxide anion radicals. These enzymes have been found in virtually all tissues and have been shown to mediate a variety of responses, including cell growth and apoptosis, angiogenesis, innate immunity, regulation of the extracellular matrix, and thyroid hormone biosynthesis.

There are seven members of the NADPH oxidase family, all of which differ in their catalytic subunit and tissue distribution. NOX1 is found in colon and vascular cells which function in host defence and cell growth; NOX2 is present in phagocytes and involved in respiration; NOX3 is found in the inner ear; NOX4 is widely distributed and NOX5 is a calcium-dependent homolog mainly expressed in lymphoid tissues. Additional members of the NADPH oxidase family include the DUOX proteins, which were identified from the thyroid gland and contain a putative peroxidase domain. In addition to the thyroid gland, DUOX1 is also found in airway epithelia and the prostate whilst DUOX2 is expressed in the gastrointestinal tract.

ROS derived from NADPH oxidase enzymes are critical for normal physiological responses, but also contribute to a growing number of diseases, including atherosclerosis, hypertension, arthritis, Alzheimer's disease, cancer and respiratory syndromes.

External sources of pharmacological information for NADPH Oxidase :

    Literature for NADPH Oxidase

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    NADPH oxidase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    NADPH oxidase 1 Human NOX1 NP_008983.2 Q9Y5S8
    Mouse Nox1 NM_172203 NP_757340
    Rat Nox1 NM_053683 NP_446135
    Cytochrome b-245, beta polypeptide (NOX2) Human CYBB NM_000397 P04839
    Mouse Cybb NM_007807 NP_031833
    Rat Cybb NM_023965 NP_076455
    NADPH oxidase 3 Human NOX3 NM_015718 Q9HBY0
    Mouse Nox3 NM_198958 NM_198958
    Rat Nox3 NM_001004216 NP_001004216
    NADPH oxidase 4 Human NOX4 NM_016931.3 Q9NPH5
    Mouse Nox4 NM_015760 NP_056575
    Rat Nox4 NM_053524 NP_445976
    NADPH oxidase, EF-hand calcium binding domain 5 Human NOX5 NM_024505.3 Q96PH1
    Mouse - - -
    Rat - - -
    Dual oxidase 1 Human DUOX1 NM_017434.3 Q9NRD9
    Mouse Duox1 NM_001099297 NP_001092767
    Rat Duox1 NM_153739 NP_714961
    Dual oxidase 2 Human DUOX2 NM_006142 P31947
    Mouse Duox2 NM_177610 NP_808278
    Rat Duox2 NM_024141 NP_077055