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NQTrp

Cat. No. 5398 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5398 has been discontinued.

说明： Potent inhibitor of Aβ oligomer and fibril formation
化学名： N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for NQTrp

NQTrp is a potent inhibitor of Aβ oligomer and fibril formation (IC50 = 50 nM for formation of fibrils from Aβ1-42). Reduces cytotoxicity of Aβ oligomers and increases cell viability in neuronal cells. Significantly extends lifespan of Drosophila expressing human Aβ1-42.

技术数据 for NQTrp

分子量 360.36
公式 C21H16N2O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 185351-19-3
PubChem ID 56605052
InChI Key DZZUYZXINNHEGM-SFHVURJKSA-N
Smiles O=C1C4=C(C=CC=C4)C(C(N[C@H]([C@@](O)=O)CC3=CNC2=CC=CC=C23)=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for NQTrp

参考文献是支持产品生物活性的出版物。

Zhang et al (2013) Atomic and dynamic insights into the beneficial effect of the 1,4-naphthoquinon-2-yl-L-tryptophan inhibitor on Alzheimer's Aβ1-42 dimer in terms of aggregation and toxicity. ACS Chem.Neurosci. 5 148 PMID: 24246047

Scherzer-Attali et al (2010) Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor. PLoS ONE 5 e11101 PMID: 20559435

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关键词: NQTrp, NQTrp supplier, amyloid, Abeta, AB, Aβ, inhibits, inhibitors, fibrils, oligomers, Alzheimer's, disease, Amyloid, Beta, Peptides, 5398, Tocris Bioscience

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