NS 1619

Name: NS 1619
Brand: Tocris Bioscience
SKU: 3804
Rating: 4.5 (2 reviews)

Cat. No. 3804 2 篇引用文献 2 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： K_Ca1.1 (BK) channel activator

化学名： 1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one

纯度： ≥98% (HPLC)

说明书

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for NS 1619

NS 1619 is a large-conductance Ca²⁺-activated potassium (BK_Ca, K_Ca1.1) channel activator. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC₅₀ = 3.6 μM).

技术数据 for NS 1619

分子量	362.23
公式	C₁₅H₈F₆N₂O₂
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	153587-01-0
PubChem ID	4552
InChI Key	YLFMCMWKHSDUCT-UHFFFAOYSA-N
Smiles	O=C2NC1=CC(C(F)(F)F)=CC=C1N2C3=CC(C(F)(F)F)=CC=C3O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NS 1619

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	36.22	100
	ethanol	36.22	100

制备储备液 for NS 1619

以下数据基于产品分子量 362.23。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.76 mL	13.8 mL	27.61 mL
5 mM	0.55 mL	2.76 mL	5.52 mL
10 mM	0.28 mL	1.38 mL	2.76 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for NS 1619

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NS 1619

参考文献是支持产品生物活性的出版物。

Olesen et al (1994) Selective activation of Ca(2+)-dependent K⁺ channels by novel benzimidazolone. Eur.J.Pharmacol. 251 53 PMID: 8137869

Debska et al (2003) Large-conductance K⁺ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells. Biochem.Pharmacol. 65 1827 PMID: 12781334

Han et al (2008) The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells. Biochem.Biophys.Res.Comm. 375 205

If you know of a relevant reference for NS 1619, please let us know.

按标靶查看相关产品

关键词: NS 1619, NS 1619 supplier, NS1619, Ca2+-activated, potassium, K+, KCa, KCa1.1, channels, activators, openers, large, conductance, BK, maxi-K, Ca2+-Activated, Potassium, Channels, 3804, Tocris Bioscience

2 篇 NS 1619 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NS 1619 的部分引用包括：

Fei et al (2021) Role for calcium-activated potassium channels (BK) in migration control of human hepatocellular carcinoma cells. J Cell Mol Med 25 9685-9696 PMID: 34514691

Khan et al (2019) BK channels regulate extracellular Tat-mediated HIV-1 LTR transactivation. Sci Rep 9 12285 PMID: 31439883

您是否知道使用了 Tocris NS 1619 的优秀论文？请告知我们.

NS 1619 的评论

平均评分: 4.5 (基于 2 条评论。)

5 星

50%

4 星

50%

3 星

2 星

1 星

Have you used NS 1619?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

BK opening for the treatment of Pulmonary Hypertension.

By Sadequl Islam on 09/13/2018

分析类型： In Vitro

种属： Rat

The effect of NS161 as a therapeutic option for pulmonary hypertension was studied in rats. It can be seen from the test results that inhalation of a 12 µM and 100 µM NS1619 solution significantly reduces RV pressure without affecting systemic arterial pressure.

NS1619 inhalation reduces RV pressure and improves oxygen supply and its application inhibits PASMC proliferation in vitro.

Standard BK channel activator with great research potential.

By Farzana Islam on 08/17/2018