NS 1619

Pricing Availability   Qty
说明: KCa1.1 (BK) channel activator
化学名: 1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
纯度: ≥98% (HPLC)
说明书
引用文献 (2)
评论 (2)

生物活性 for NS 1619

NS 1619 is a large-conductance Ca2+-activated potassium (BKCa, KCa1.1) channel activator. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC50 = 3.6 μM).

技术数据 for NS 1619

分子量 362.23
公式 C15H8F6N2O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 153587-01-0
PubChem ID 4552
InChI Key YLFMCMWKHSDUCT-UHFFFAOYSA-N
Smiles O=C2NC1=CC(C(F)(F)F)=CC=C1N2C3=CC(C(F)(F)F)=CC=C3O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NS 1619

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.22 100
ethanol 36.22 100

制备储备液 for NS 1619

以下数据基于产品分子量 362.23。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.76 mL 13.8 mL 27.61 mL
5 mM 0.55 mL 2.76 mL 5.52 mL
10 mM 0.28 mL 1.38 mL 2.76 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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产品说明书 for NS 1619

分析证书/产品说明书
选择另一批次:

参考文献 for NS 1619

参考文献是支持产品生物活性的出版物。

Olesen et al (1994) Selective activation of Ca(2+)-dependent K+ channels by novel benzimidazolone. Eur.J.Pharmacol. 251 53 PMID: 8137869

Debska et al (2003) Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells. Biochem.Pharmacol. 65 1827 PMID: 12781334

Han et al (2008) The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells. Biochem.Biophys.Res.Comm. 375 205


If you know of a relevant reference for NS 1619, please let us know.

关键词: NS 1619, NS 1619 supplier, NS1619, Ca2+-activated, potassium, K+, KCa, KCa1.1, channels, activators, openers, large, conductance, BK, maxi-K, Ca2+-Activated, Potassium, Channels, 3804, Tocris Bioscience

2 篇 NS 1619 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NS 1619 的部分引用包括:

Fei et al (2021) Role for calcium-activated potassium channels (BK) in migration control of human hepatocellular carcinoma cells. J Cell Mol Med 25 9685-9696 PMID: 34514691

Khan et al (2019) BK channels regulate extracellular Tat-mediated HIV-1 LTR transactivation. Sci Rep 9 12285 PMID: 31439883


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BK opening for the treatment of Pulmonary Hypertension.
By Sadequl Islam on 09/13/2018
分析类型: In Vitro
种属: Rat

The effect of NS161 as a therapeutic option for pulmonary hypertension was studied in rats. It can be seen from the test results that inhalation of a 12 µM and 100 µM NS1619 solution significantly reduces RV pressure without affecting systemic arterial pressure.

NS1619 inhalation reduces RV pressure and improves oxygen supply and its application inhibits PASMC proliferation in vitro.


Standard BK channel activator with great research potential.
By Farzana Islam on 08/17/2018
分析类型: In Vitro
种属: Human
细胞系/组织: HEK 293

I have used NS1619 as the standard BK channel opener compound to study how its effect measures up to few other drugs known to have BK channel activation properties. Concentrations of 0.1 microM, 1 microM, 10 microM and 100 microM were made. NS1619 was dissolved in sterile DMSO. Absorbance given off by HEK 293 cells when treated by both NS1619 and test compounds were measured by flame AAS.

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