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Submit ReviewNS 1619 is a large-conductance Ca2+-activated potassium (BKCa, KCa1.1) channel activator. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC50 = 3.6 μM).
分子量 | 362.23 |
公式 | C15H8F6N2O2 |
储存 | Store at +4°C |
纯度 | ≥98% (HPLC) |
CAS Number | 153587-01-0 |
PubChem ID | 4552 |
InChI Key | YLFMCMWKHSDUCT-UHFFFAOYSA-N |
Smiles | O=C2NC1=CC(C(F)(F)F)=CC=C1N2C3=CC(C(F)(F)F)=CC=C3O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 36.22 | 100 | |
ethanol | 36.22 | 100 |
以下数据基于产品分子量 362.23。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.76 mL | 13.8 mL | 27.61 mL |
5 mM | 0.55 mL | 2.76 mL | 5.52 mL |
10 mM | 0.28 mL | 1.38 mL | 2.76 mL |
50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
参考文献是支持产品生物活性的出版物。
Olesen et al (1994) Selective activation of Ca(2+)-dependent K+ channels by novel benzimidazolone. Eur.J.Pharmacol. 251 53 PMID: 8137869
Debska et al (2003) Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells. Biochem.Pharmacol. 65 1827 PMID: 12781334
Han et al (2008) The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells. Biochem.Biophys.Res.Comm. 375 205
If you know of a relevant reference for NS 1619, please let us know.
关键词: NS 1619, NS 1619 supplier, NS1619, Ca2+-activated, potassium, K+, KCa, KCa1.1, channels, activators, openers, large, conductance, BK, maxi-K, Ca2+-Activated, Potassium, Channels, 3804, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 NS 1619 的部分引用包括:
Fei et al (2021) Role for calcium-activated potassium channels (BK) in migration control of human hepatocellular carcinoma cells. J Cell Mol Med 25 9685-9696 PMID: 34514691
Khan et al (2019) BK channels regulate extracellular Tat-mediated HIV-1 LTR transactivation. Sci Rep 9 12285 PMID: 31439883
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The effect of NS161 as a therapeutic option for pulmonary hypertension was studied in rats. It can be seen from the test results that inhalation of a 12 µM and 100 µM NS1619 solution significantly reduces RV pressure without affecting systemic arterial pressure.
NS1619 inhalation reduces RV pressure and improves oxygen supply and its application inhibits PASMC proliferation in vitro.
I have used NS1619 as the standard BK channel opener compound to study how its effect measures up to few other drugs known to have BK channel activation properties. Concentrations of 0.1 microM, 1 microM, 10 microM and 100 microM were made. NS1619 was dissolved in sterile DMSO. Absorbance given off by HEK 293 cells when treated by both NS1619 and test compounds were measured by flame AAS.