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NS 1643

Cat. No. 3062 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： KV11.1 (hERG) channel activator; antiarrhythmic
化学名： N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NS 1643

NS 1643 is a human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM). Exhibits different molecular mechanisms of action at KV11.1 (hERG1) and KV11.2 (hERG2) channels. Displays antiarrhythmic activity in vitro.

技术数据 for NS 1643

分子量 380.24
公式 C15H10F6N2O3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 448895-37-2
PubChem ID 10177784
InChI Key NJFVQMRYJZHGME-UHFFFAOYSA-N
Smiles OC1=C(NC(NC2=C(O)C=CC(C(F)(F)F)=C2)=O)C=C(C(F)(F)F)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NS 1643

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 38.02 100
DMSO 9.51 25

制备储备液 for NS 1643

以下数据基于产品分子量 380.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.63 mL 13.15 mL 26.3 mL
5 mM 0.53 mL 2.63 mL 5.26 mL
10 mM 0.26 mL 1.31 mL 2.63 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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产品说明书 for NS 1643

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for NS 1643

参考文献是支持产品生物活性的出版物。

Hansen et al (2006) Activation of human ether-a-go-go related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643). Mol.Pharmacol. 69 266 PMID: 16219910

Casis et al (2006) Mechanism of action of a novel human ether-a-go-ao related gene channel activator. Mol.Pharmacol. 69 658 PMID: 16284303

Elmedyb et al (2007) Activation of ERG2 potassium channel by the diphenylurea NS1643. Neuropharmacology 53 283 PMID: 17610913

If you know of a relevant reference for NS 1643, please let us know.

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关键词: NS 1643, NS 1643 supplier, hERG, channel, activators, Antiarrhythmic, Potassium, KV, Channels, Human, Ether-A-Go-Go, Gene, voltage-gated, voltage-dependent, K+, NS1643, Voltage-Gated, 3062, Tocris Bioscience

1 篇 NS 1643 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NS 1643 的部分引用包括：

Perissinotti et al (2015) Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel. Biophys J 108 1414 PMID: 25809254

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NS 1643 的评论

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Standard K.v channel opener: Performed well in biological channel activation studies.
By Sadequl Islam on 10/12/2018
分析类型： In Vitro
种属： Mouse

NS 1643 was used to understand its potassium channel opening properties. The product performed well under experimental conditions. Dissolving in ethanol is a better option than disssolving in DMSO as opposed to other K.V channel openers.

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